부산대학교 도서관

Radiation-inducednormal tissue toxicity is acommon acute and chronic outcome of radiotherapy (RT) for prostate cancer (PCa). There are currently no existing pre-assessments before treatment to predict acute and late RT-induced toxicity. Novel predictive blood biomarkers in radiation oncology may improve treatment decision-making and therapeutic monitoring for patients with PCa. A comprehensive systematic search of microRNA (miRNA/miR) profiling studies published in PubMed, Science Direct and Google Scholar was performed. The present systematic review, supported by meta-analysis, summarises key findings and discusses the results of prospective clinical studies investigating miRNA expression levels and their association with RT-induced toxicity in PCa. Out of seven clinical studies, six highlighted levels of 10 miRNAs changing in plasma, serum or peripheral blood mononuclear cells during RT. The post-RT expression levels of miRNA-132-5p, miRNA-1-3p, miRNA-410 and miRNA-221 were increased, and miRNA-23a-3p expression was decreased among patients with low-grade RT-induced toxicity. Furthermore, in patients with high-grade RT toxicity, miRNA-197-3p, miRNA-151a-5p, miRNA-18b-5p, miRNA-99a and miRNA-21 expression was increased, while miRNA-132-5p expression was decreased. The present miRNA meta-analysis could be the focus of future studies to identify their potential clinical value as PCa biomarkers and therapeutic mediators in RT-induced toxicity. The variations in miRNA levels post-RT could be used as predictive biomarkers of RT-induced toxicity. However, further extensive validation is required to establish the relationship between miRNA expression levels and RT-induced toxicity in PCa and to confirm their predictive value. Key words: prostate cancer, radiotherapy, radiotherapy-induced toxicity, plasma or serum, microRNA expression
Introduction Prostate cancer (PCa) is the second most frequently diagnosed malignancy (excluding non-melanoma skin cancer) and is the fifth leading cause of cancer-related mortality in men worldwide (1,2). According to [...]