학술논문
Advances in the Relationship between Respiratory Viruses and Asthma
Document Type
Report
Author
Source
Journal of Clinical Medicine. August 2023, Vol. 12 Issue 17
Subject
Language
English
ISSN
2077-0383
Abstract
Author(s): Sergio de Jesús Romero-Tapia (corresponding author) [1,*]; Crystell Guadalupe Guzmán Priego [2]; Blanca E. Del-Río-Navarro [3]; Manuel Sánchez-Solis [4,5] 1. Viral Infections as a Risk Factor for Asthma Asthma [...]
Several studies have reported that viral infection is closely associated with the onset, progression, and exacerbation of asthma. The purpose of this review is to summarize the role that viral infections have in the pathogenesis of asthma onset and exacerbations, as well as discuss interrelated protective and risk factors of asthma and current treatment options. Furthermore, we present current knowledge of the innate immunological pathways driving host defense, including changes in the epithelial barrier. In addition, we highlight the importance of the genetics and epigenetics of asthma and virus susceptibility. Moreover, the involvement of virus etiology from bronchiolitis and childhood wheezing to asthma is described. The characterization and mechanisms of action of the respiratory viruses most frequently related to asthma are mentioned.
Several studies have reported that viral infection is closely associated with the onset, progression, and exacerbation of asthma. The purpose of this review is to summarize the role that viral infections have in the pathogenesis of asthma onset and exacerbations, as well as discuss interrelated protective and risk factors of asthma and current treatment options. Furthermore, we present current knowledge of the innate immunological pathways driving host defense, including changes in the epithelial barrier. In addition, we highlight the importance of the genetics and epigenetics of asthma and virus susceptibility. Moreover, the involvement of virus etiology from bronchiolitis and childhood wheezing to asthma is described. The characterization and mechanisms of action of the respiratory viruses most frequently related to asthma are mentioned.