부산대학교 도서관

Our aim was to provide a descriptive overview of how the birth defects surveillance and folic acid fortification programs were implemented in Costa Rica--through the establishment of the Registry Center for Congenital Anomalies (Centro de Registro de Enfermedades Congenitas--CREC), and fortification legislation mandates. We estimated the overall prevalence of neural tube defects (i.e., spina bifida, anencephaly and encephalocele) before and after fortification captured by CREC. Prevalence was calculated by dividing the total number of infants born with neural tube defects by the total number of live births in the country (1987-2012).A total of 1,170 newborns with neural tube defects were identified from 1987 to 2012 (1992-1995 data excluded); 628 were identified during the baseline pre-fortification period (1987-1991; 1996-1998); 191 during the fortification period (1999-2002); and 351 during the post-fortification time period (2003-2012). The overall prevalence of neural tube defects decreased from 9.8 per 10,000 live-births (95% CI 9.1-10.5) for the pre-fortification period to 4.8 per 10,000 live births (95% CI 4.3-5.3) for the post-fortification period. Results indicate a statistically significant (P < 0.05) decrease of 51% in the prevalence of neural tube defects from the pre-fortification period to the post-fortification period. Folic acid fortification via several basic food sources has shown to be a successful public health intervention for Costa Rica. Costa Rica's experience can serve as an example for other countries seeking to develop and strengthen both their birth defects surveillance and fortification programs. Keywords Surveillance * Fortification * Costa Rica * Prevalence * Neural tube defects
Introduction Approximately 300,000 neural tube defects occur each year worldwide [1]. Neural tube defects, such as spina bifida, anencephaly, and encephalocele, are severe birth defects that affect the development of [...]