학술논문
Physiologically‐based pharmacokinetic modeling for primary metabolites of CYP3A and P‐glycoprotein inhibitors in drug–drug interactions: Should we assume the free drug hypothesis?
Document Type
Academic Journal
Source
CPT: Pharmacometrics & Systems Pharmacology. January 2023, Vol. 12 Issue 1, p8, 5 p.
Subject
Language
English
Abstract
INTRODUCTION Metabolites of perpetrators may contribute to drug–drug interactions (DDIs) mediated by inhibition/induction of drug‐metabolizing enzymes and transporters. Using physiologically‐based pharmacokinetic (PBPK) modeling, we provide our perspective on the model‐predicted [...]