학술논문
Monoclonal gammopathy of renal significance presenting with cryoglobulinemia type I-associated severe thrombotic microangiopathy
Document Type
Academic Journal
Source
Clinical Kidney Journal. July, 2022, Vol. 15 Issue 7, p1425, 4 p.
Subject
Language
English
ISSN
2048-8505
Abstract
We report a 53-year-old man who presented with acute renal failure. His medical history revealed a spondyloarthropathy, for which secukinumab was started recently, and a monoclonal gammopathy of unknown significance. Kidney function deteriorated despite the withdrawal of secukinumab and dialysis was started. In the serum, type 1 cryoglobulins were present and a kidney biopsy showed ischaemic glomeruli, with thrombosis of the larger interlobular arteries. Other causes of thrombotic microangiopathy were excluded. Bone marrow immunophenotyping showed 1% monoclonal plasma cells. A diagnosis of monoclonal gammopathy of renal significance was made. Haematological treatment resulted in haematological and renal response. Keywords: acute renal failure, cryoglobulinemia, monoclonal gammopathy of renal significance, thrombotic microangiopathy
INTRODUCTION Cryoglobulinemia is defined by the presence in serum of immunoglobulins that precipitate with cold temperature and dissolve with rewarming. Kidney involvement occurs in 20-30% of patients with cryoglobulin-associated systemic [...]
INTRODUCTION Cryoglobulinemia is defined by the presence in serum of immunoglobulins that precipitate with cold temperature and dissolve with rewarming. Kidney involvement occurs in 20-30% of patients with cryoglobulin-associated systemic [...]