학술논문
The ongoing evolution of variants of concern and interest of SARS-CoV-2 in Brazil revealed by convergent indels in the amino (N)-terminal domain of the spike protein
Document Type
Report
Author
Resende, Paola Cristina; Naveca, Felipe G.; Lins, Roberto D.; Dezordi, Filipe Zimmer; Ferraz, Matheus V.F.; Moreira, Emerson G.; Coelho, Danilo F.; Motta, Fernando Couto; Paixao, Anna Carolina Dias; Appolinario, Luciana; Lopes, Renata Serrano; da Fonseca Mendonca, Ana Carolina; da Rocha, Alice Sampaio Barreto; Nascimento, Valdinete; Souza, Victor; Silva, George; Nascimento, Fernanda; Neto, Lidio Goncalves Lima; da Silva, Fabiano Vieira; Riediger, Irina; Debur, Maria do Carmo; Leite, Anderson Brandao; Mattos, Tirza; da Costa, Cristiano Fernandes; Pereira, Felicidade Mota; dos Santos, Cliomar Alves; Rovaris, Darcita Buerger; Fernandes, Sandra Bianchini; Abbud, Adriano; Sacchi, Claudio; Khouri, Ricardo; Bernardes, Andre Felipe Leal; Delatorre, Edson; Graf, Tiago; Siqueira, Marilda Mendonca; Bello, Gonzalo; Wallau, Gabriel L.
Source
Virus Evolution. November, 2021, Vol. 7 Issue 2, p1t, p11 p.
Subject
Language
English
Abstract
Mutations at both the receptor-binding domain (RBD) and the amino (N)-terminal domain (NTD) of the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Spike (S) glycoprotein can alter its antigenicity and promote immune escape. We identified that SARS-CoV-2 lineages circulating in Brazil with mutations of concern in the RBD independently acquired convergent deletions and insertions in the NTD of the S protein, which altered the NTD antigenic-supersite and other predicted epitopes at this region. Importantly, we detected the community transmission of different P.1 lineages bearing NTD indels [DELTA]69-70 (which can impact several SARS-CoV-2 diagnostic protocols), A144 and ins214ANRN, and a new VOI N.10 derived from the B.1.1.33 lineage carrying three NTD deletions ([DELTA]141-144, [DELTA]211, and [DELTA]256-258). These findings support that the ongoing widespread transmission of SARS-CoV-2 in Brazil generates new viral lineages that might be more resistant to antibody neutralization than parental variants of concern. Key words: COVID-19; pandemics; antibody escape; SARS-CoV-2; community transmission
1. Introduction Recurrent deletions in the amino (N)-terminal domain (NTD) of the spike (S) glycoprotein of SARS-CoV-2 have been identified during long-term infection of immunocompromised patients (Avanzato et al. 2020; [...]
1. Introduction Recurrent deletions in the amino (N)-terminal domain (NTD) of the spike (S) glycoprotein of SARS-CoV-2 have been identified during long-term infection of immunocompromised patients (Avanzato et al. 2020; [...]