부산대학교 도서관

To purchase or authenticate to the full-text of this article, please visit this link: http://dx.doi.org/10.1111/j.1365-2044.2007.05230.x Byline: C. W. Cheung (1), C. L. A. Ying (2), W. K. Chiu (3), G. T. C. Wong (1), K. F. J. Ng (4), M. G. Irwin (4) Abstract: Summary This randomised, double-blind study compared dexmedetomidine and midazolam for intravenous sedation during third molar surgery under local anaesthesia. Sixty patients received either dexmedetomidine (up to 1 [mu]g.kg.sup.-1) or midazolam (up to 5 mg), which was infused until the Ramsay Sedation Score was four or the maximum dose limit was reached. Intra-operative vital signs, postoperative pain scores and analgesic consumption, amnesia, and satisfaction scores for patients and surgeons, were recorded. Sedation was achieved by median (IQR (range)) doses of 47 [mu]g (39-52 (25-76)) or 0.88 [mu]g.kg.sup.-1 (0.75-1.0 (0.6-1.0)) dexmedetomidine, and 3.6 mg (3.3-4.4 (1.9-5.0)) or 0.07 mg.kg.sup.-1 (0.055-0.085 (0.017-0.12)) midazolam. Heart rate and blood pressure during surgery were lower in dexmedetomidine group. There was no significant difference in satisfaction or pain scores. Midazolam was associated with greater amnesia. Dexmedetomidine produces comparable sedation to midazolam. Author Affiliation: (1) Assistant Professors (2) Medical Student (4) Associate Professors, Department of Anaesthesiology, the University of Hong Kong, Room 424, Block K, Queen Mary Hospital, 102 Pokfulam Road, Hong Kong (3) Assistant Professor in Oral and Maxillofacial. Surgery, Faculty of Dentistry, the University of Hong Kong Article History: Accepted: 24 April 2007 Article note: Dr Chi Wai Cheung E-mail: cheucw@hku.hk