학술논문
A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome. (Research Article)
Document Type
Academic Journal
Author
Mural, Richard J.; Adams, Mark D.; Myers, Eugene W.; Smith, Hamilton O.; Miklos, George L. Gabor; Wides, Ron; Halpern, Aaron; Li, Peter W.; Sutton, Granger G.; Nadeau, Joe; Salzberg, Steven L.; Holt, Robert A.; Kodira, Chinnappa D.; Lu, Fu; Chen, Lin; Deng, Zuoming; Evangelista, Carlos C.; Gan, Weiniu; Heiman, Thomas J.; Li, Jiayin; Li, Zhenya; Merkulov, Gennady V.; Milshina, Natalia V.; Naik, Ashwinikumar K.; Qi, Rong; Shue, Bixiong Chris; Wang, Aihui; Wang, Jian; Wang, Xin; Yan, Xianghe; Ye, Jane; Yooseph, Shibu; Zhao, Qi; Zheng, Liansheng; Zhu, Shiaoping C.; Biddick, Kendra; Bolanos, Randall; Delcher, Arthur L.; Dew, Ian M.; Fasulo, Daniel; Flanigan, Michael J.; Huson, Daniel H.; Kravitz, Saul A.; Miller, Jason R.; Mobarry, Clark M.; Reinert, Knut; Remington, Karin A.; Zhang, Qing; Zheng, Xiangqun H.; Nusskern, Deborah R.; Lai, Zhongwu; Lei, Yiding; Zhong, Wenyan; Yao, Alison; Guan, Ping; Ji, Rui-Ru; Gu, Zhiping; Wang, Zhen-Yuan; Zhong, Fei; Xiao, Chunlin; Chiang, Chia-Chien; Yandell, Mark; Wortman, Jennifer R.; Amanatides, Peter G.; Hladun, Suzanne L.; Pratts, Eric C.; Johnson, Jeffery E.; Dodson, Kristina L.; Woodford, Kerry J.; Evans, Cheryl A.; Gropman, Barry; Rusch, Douglas B.; Venter, Eli; Wang, Mei; Smith, Thomas J.; Houck, Jarrett T.; Tompkins, Donald E.; Haynes, Charles; Jacob, Debbie; Chin, Soo H.; Allen, David R.; Dahlke, Carl E.; Sanders, Robert; Li, Kelvin; Liu, Xiangjun; Levitsky, Alexander A.; Majoros, William H.; Chen, Quan; Xia, Ashley C.; Lopez, John R.; Donnelly, Michael T.; Newman, Matthew H.; Glodek, Anna; Kraft, Cheryl L.; Nodell, Marc; Ali, Feroze; An, Hui-Jin; Baldwin-Pitts, Danita; Beeson, Karen Y.; Cai, Shuang; Carnes, Mark; Carver, Amy; Caulk, Parris M.; Center, Angela; Chen, Yen-Hui; Cheng, Ming-Lai; Coyne, My D.; Crowder, Michelle; Danaher, Steven; Davenport, Lionel B.; Desilets, Raymond; Dietz, Susanne M.; Doup, Lisa; Dullaghan, Patrick; Ferriera, Steven; Fosler, Carl R.; Gire, Harold C.; Gluecksmann, Andres; Gocayne, Jeannine D.; Gray, Jonathan; Hart, Brit; Haynes, Jason; Hoover, Jeffery; Howland, Tim; Ibegwam, Chinyere; Jalali, Mena; Johns, David; Kline, Leslie; Ma, Daniel S.; MacCawley, Steven; Magoon, Anand; Mann, Felecia; May, David; McIntosh, Tina C.; Mehta, Somil; Moy, Linda; Moy, Mee C.; Murphy, Brian J.; Murphy, Sean D.; Nelson, Keith A.; Nuri, Zubeda; Parker, Kimberly A.; Prudhomme, Alexandre C.; Puri, Vinita N.; Qureshi, Hina; Raley, John C.; Reardon, Matthew S.; Regier, Megan A.; Rogers, Yu-Hui C.; Romblad, Deanna L.; Schutz, Jakob; Scott, John L.; Scott, Richard; Sitter, Cynthia D.; Smallwood, Michella; Sprague, Arlan C.; Stewart, Erin; Strong, Renee V.; Suh, Ellen; Sylvester, Karena; Thomas, Reginald; Tint, Ni Ni; Tsonis, Christopher; Wang, Gary; Wang, George; Williams, Monica S.; Williams, Sherita M.; Windsor, Sandra M.; Wolfe, Keriellen; Wu, Mitchell M.; Zaveri, Jayshree; Chaturvedi, Kabir; Gabrielian, Andrei E.; Ke, Zhaoxi; Sun, Jingtao; Subramanian, Gangadharan; Venter, J. Craig
Source
Science. May 31, 2002, Vol. 296 Issue 5573, p1661, 11 p.
Subject
Language
English
ISSN
0036-8075
Abstract
The high degree of similarity between the mouse and human genomes is demonstrated through analysis of the sequence of mouse chromosome 16 (Mmu 16), which was obtained as part of a whole-genome shotgun assembly of the mouse genome. The mouse genome is about 10% smaller than the human genome, owing to a lower repetitive DNA content. Comparison of the structure and protein-coding potential of Mmu 16 with that of the homologous segments of the human genome identifies regions of conserved synteny with human chromosomes (Hsa) 3, 8, 12, 16, 21, and 22. Gene content and order are highly conserved between Mmu 16 and the syntenic blocks of the human genome. Of the 731 predicted genes on Mmu 16, 509 align with orthologs on the corresponding portions of the human genome, 44 are likely paralogous to these genes, and 164 genes have homologs elsewhere in the human genome; there are 14 genes for which we could find no human counterpart.
The laboratory mouse is an invaluable model for helping us understand human biology and disease. The mouse genome sequence, in combination with the recently reported human genome sequence (1, 2), [...]
The laboratory mouse is an invaluable model for helping us understand human biology and disease. The mouse genome sequence, in combination with the recently reported human genome sequence (1, 2), [...]