학술논문
The alteration and significance of surfactant protein A in rats chronically exposed to cigarette smoke
Document Type
Academic Journal
Author
Source
Journal of Huazhong University of Science and Technology. April, 2008, Vol. 28 Issue 2, p128, 4 p.
Subject
Language
English
ISSN
1672-0733
Abstract
In order to confirm the alteration and significance of cigarette smoke exposure on SP-A in rats, 20 Wistar rats were assigned randomly to two groups: an N group (n=10), and an S group (n=10). The ultra-structural change was observed by electron microscopy. The number of cells positive for SPA was by immunohistochemically measured. The mRNA expression in the lung tissues was determined by reverse transcription polymerase chain reaction (RT-PCR). The number of cells positive for SPA of the S group (0.52 +- 0.05) was lower than that of the N group (0.72+-0.06) (P