학술논문
Cholesterol balance and metabolism in mice with loss of function of Niemann-Pick C protein
Document Type
Academic Journal
Source
The American Journal of Physiology. Feb, 1999, Vol. 276 Issue 2, pE336, 9 p.
Subject
Language
ISSN
0002-9513
Abstract
Experiments were performed to measure the effects of a mutation in the Niemann-Pick C (NPC) protein in mice. The studies also sought to identify the effect of the mutation on sterol metabolism in various organs, cholesterol metabolism in the brain and intracellular cholesterol degradation in the liver. It was observed that many unsterified cholesterol do not reach the site for regulation of sterol balance and that tissues where these cholesterol lodge increase their production of sterols.