학술논문
Association of Short-Term Exposure to PM[sub.2.5] with Blood Lipids and the Modification Effects of Insulin Resistance: A Panel Study in Wuhan
Document Type
Academic Journal
Source
Toxics. November 2022, Vol. 10 Issue 11
Subject
Language
English
ISSN
2305-6304
Abstract
Author(s): Jinhui Sun [1,2]; Shouxin Peng [1,2]; Zhaoyuan Li [1,2]; Feifei Liu [1,2]; Chuangxin Wu [1,2]; Yuanan Lu (corresponding author) [3,*]; Hao Xiang (corresponding author) [1,2,*] 1. Introduction Plenty of [...]
Results of previous studies about the acute effects of fine particulate matter (PM[sub.2.5]) on blood lipids were inconsistent. This study aimed to quantify the short-term effects of PM[sub.2.5] on blood lipids and estimate the modifying role of insulin resistance, reflected by the homeostasis model assessment of insulin resistance (HOMA-IR). From September 2019 to January 2020, the study recruited 70 healthy adults from Wuhan University for a total of eight repeated data collections. At each visit, three consecutive days were monitored for personal exposure to PM[sub.2.5], and then a physical examination was carried out on the fourth day. The linear mixed-effect models were operated to investigate the impact of PM[sub.2.5] over diverse exposure windows on blood lipids. With the median of the HOMA-IR 1.820 as the cut-off point, participants were assigned to two groups for the interaction analyses. We found the overall mean level (standard deviation, SD) of PM[sub.2.5] was 38.34 (18.33) μg/m[sup.3]. Additionally, with a 10 μg/m[sup.3] rise in PM[sub.2.5], the corresponding largest responses in triglyceride (TG), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), as well as high-density lipoprotein cholesterol (HDL-C), were −0.91% (95% confidence interval (CI): −1.63%, −0.18%), −0.33% (95% CI: −0.64%, −0.01%,), −0.94% (95% CI: −1.53%, −0.35%), and 0.67% (95% CI: 0.32%, 1.02%), respectively. The interaction analyses revealed that a significantly greater reduction in the four lipids corresponded to PM[sub.2.5] exposure when in the group with the lower HOMA-IR (
Results of previous studies about the acute effects of fine particulate matter (PM[sub.2.5]) on blood lipids were inconsistent. This study aimed to quantify the short-term effects of PM[sub.2.5] on blood lipids and estimate the modifying role of insulin resistance, reflected by the homeostasis model assessment of insulin resistance (HOMA-IR). From September 2019 to January 2020, the study recruited 70 healthy adults from Wuhan University for a total of eight repeated data collections. At each visit, three consecutive days were monitored for personal exposure to PM[sub.2.5], and then a physical examination was carried out on the fourth day. The linear mixed-effect models were operated to investigate the impact of PM[sub.2.5] over diverse exposure windows on blood lipids. With the median of the HOMA-IR 1.820 as the cut-off point, participants were assigned to two groups for the interaction analyses. We found the overall mean level (standard deviation, SD) of PM[sub.2.5] was 38.34 (18.33) μg/m[sup.3]. Additionally, with a 10 μg/m[sup.3] rise in PM[sub.2.5], the corresponding largest responses in triglyceride (TG), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), as well as high-density lipoprotein cholesterol (HDL-C), were −0.91% (95% confidence interval (CI): −1.63%, −0.18%), −0.33% (95% CI: −0.64%, −0.01%,), −0.94% (95% CI: −1.53%, −0.35%), and 0.67% (95% CI: 0.32%, 1.02%), respectively. The interaction analyses revealed that a significantly greater reduction in the four lipids corresponded to PM[sub.2.5] exposure when in the group with the lower HOMA-IR (