부산대학교 도서관

To purchase or authenticate to the full-text of this article, please visit this link: http://dx.doi.org/10.1111/j.1468-1293.2006.00352.x Byline: KCW Chan, KH Wong, SS Lee Keywords: AIDS; antiretroviral therapy; CD4 cell count; minority communities; survival Abstract: Objective Reductions in HIV/AIDS mortality associated with highly active antiretroviral therapy (HAART) have mainly been reported from Western countries. We studied the impact on survival of patients with advanced HIV disease after the introduction of HAART in Hong Kong. Methods The mortality pattern in a government clinic cohort of 511 adult HIV-1-infected patients with AIDS or CD4 count Results Despite an increase in the patient population, 36 deaths occurred in the HAART era (1997-2002) as compared with 56 deaths in the pre-HAART era (1993-1996). The overall annual CMR fell significantly from a high, fluctuating level of 10.8-30.4 per 100 mid-year patient population pre-HAART to a low, steady level of 0.8-6.9 per 100 mid-year population in the HAART era (P=0.004, 1996 vs 1998; P Conclusion There was dramatic temporal decline in mortality in patients with advanced HIV disease in all demographic subpopulations with the advent of HAART. Notwithstanding confounding variables, one reason for the universal decline may be that there was no major disparity in access to HIV care across community groups. Article History: Received: 17 March 2005, accepted 30 June 2005 Article note: Correspondence: Dr K. H. Wong, Special Preventive Programme, Centre for Health Protection, Department of Health, 5/F, Yaumatei Jockey Club Clinic, 145 Battery Street, Kowloon, Hong Kong. Tel: (852) 2780 4390; fax: (852) 2780 9580; e-mail: khwong@dhspp.net