학술논문
Characterization of the human cysteinyl leukotriene CysLT1 receptor
Document Type
Academic Journal
Author
Lynch, Kevin R.; O'Neill, Gary P.; Liu, Qingyun; Im, Dong-Soon; Sawyer, Nicole; Metters, Kathleen M.; Coulombe, Nathalie; Abramovitz, Mark; Figueroa, David J.; Zeng, Zhizhen; Connolly, Brett M.; Bai, Chang; Austin, Christopher P.; Chateauneuf, Anne; Stocco, Rino; Greig, Gillian M.; Kargman, Stacia; Hooks, Shelley B.; Hosfield, Elizabeth; Williams, David L., Jr.; Ford-Hutchinson, Anthony W.; Caskey, C. Thomas; Evans, Jilly F.
Source
Nature. June 24, 1999, Vol. 399 Issue 6738, p789, 5 p.
Subject
Language
ISSN
0028-0836
Abstract
It has been possible to characterize the human orphan G-protein-coupled receptor HG55 as the CysLT1 receptor. Two different Xenopus laevis functional systems were used to characterize GH55 (CysLT1)-receptor activation. It was found that all three marketed cysteinyl leukotriene antagonists, zafirlukast (Accolate), montelukast (Singulair) and pranlukast (Onon) are potent competitors for the binding of radiolabelled leukotriene D4 to the CysLT1 receptor.