학술논문
A polymorphism in the CTGF promoter region associated with systemic sclerosis
Document Type
Clinical report
Author
Fonseca, Carmen; Lindahl, Gisela E.; Ponticos, Markella; Sestini, Piersante; Renzoni, Elisabetta A.; Holmes, Alan M.; Spagnolo, Paolo; Pantelidis, Panagiotis; Leoni, Patricia; McHugh, Neil; Stock, Carmel J.; Xu Shi-Wen; Penton, Christopher P.; Black, Carol M.; Welsh, Kenneth I.; du Bois, Ronald M.; Abraham, David J.
Source
The New England Journal of Medicine. Sept 20, 2007, Vol. 357 Issue 12, p1210, 11 p.
Subject
Language
English
ISSN
0028-4793
Abstract
A polymorphism is genotyped in the promoter of the connective-tissue growth factor (CTGF) to study more about systemic sclerosis (scleroderma), an autoimmune disease. The results show that the polymorphism helps in the treatment of the disease by repressing the CTGF transcription.