학술논문
Ligand recognition by E-selectin: synthesis, inhibitory activity, and conformational analysis of bivalent sialyl Lewis x analogs
Document Type
Academic Journal
Author
Source
Journal of the American Chemical Society. Jan 11, 1995, Vol. 117 Issue 1, p66, 14 p.
Subject
Language
ISSN
0002-7863
Abstract
Chemoenzymatically prepared sialyl Lewis x dimers anchored onto a galactose template or attached to 1, 4-butanediol or 1,5-pentanediol show higher activity than the sialyl Lewis x pentasaccharide. The monomeric conformation is retained by the sialyl Lewis x domain of the dimer. These dimers serve as inhibitors of E-selection-mediated cell adhesion and exhibit different patterns of activity, which is due to variations in the orientation and distance between the monomer domains.