학술논문
Induced Alpha-helix structure in the aryl hydrocarbon receptor transactivation domain modulates protein-protein interactions
Document Type
Academic Journal
Source
Biochemistry. Jan 18, 2005, Vol. 44 Issue 2, p734, 10 p.
Subject
Language
English
ISSN
0006-2960
Abstract
Steady-state intrinsic tryptophan fluorescence and circular dichroism spectroscopy are used to investigate the conformation of the acidic Q-rich region. The findings support a role for protein folding in the aryl hydrocarbon receptor (AhR) action and suggest possible mechanisms of receptor-dependent gene activation.