학술논문
Identification of an active site of EMMPRIN for the augmentation of matrix metalloproteinase-1 and -3 expression in a co-culture of human uterine cervical carcinoma cells and fibroblasts
Document Type
Report
Source
Gynecologic Oncology. August, 2009, Vol. 114 Issue 2, p337, 6 p.
Subject
Language
English
ISSN
0090-8258
Abstract
To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.ygyno.2009.04.004 Byline: Takashi Sato (a), Tomoko Ota (a), Mami Watanabe (a), Keisuke Imada (a), Motoyoshi Nomizu (b), Akira Ito (a) Keywords: EMMPRIN; Matrix metalloproteinase; Human uterine cervical carcinoma; Co-culture; Systematic peptide screening Abstract: Extracellular matrix metalloproteinase inducer (EMMPRIN) is highly expressed on malignant tumor cell surface and accelerates tumor invasion. We previously reported that human uterine cervical carcinoma SKG-II cells exhibit the progression of in-vitro invasiveness by utilizing the enhanced production of matrix metalloproteinase (MMP) in human uterine cervical fibroblasts (HUCF) under an in-vitro co-culture model (Sato T et al., Gynecol Oncol 2004; 92:47-56). The aim of this study was to clarify the active site of EMMPRIN in the augmentation of MMP production in the co-culture of SKG-II cells and HUCF. Author Affiliation: (a) Department of Biochemistry and Molecular Biology, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, Japan (b) Laboratory of Clinical Biochemistry, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, Japan Article History: Received 18 February 2009 Article Note: (footnote) [star] The nucleotide sequence data of EMMPRIN reported in this paper have been submitted to the DDBJ/EMBL/GenBank nucleotide sequence database with the accession number AB072923.