학술논문
Quantitative and Topographic Analysis by Immunohistochemical Expression of Ghrelin Gastric Cells in Patients with Morbid Obesity
Document Type
Academic Journal
Author
Source
Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy. August 31, 2020, Vol. 13, p2855, 10 p.
Subject
Language
English
ISSN
1178-7007
Abstract
Purpose: The cellular distribution of ghrelin positive cells is not well defined. The aim of the study is to quantify and determine the distribution of ghrelin cells in gastric mucosa in patients with morbid obesity and relate this finding to gender, comorbidities, gastritis, and plasmatic levels of acyl and desacylghrelin before and after laparoscopic sleeve gastrectomy. Patient and Methods: We performed a study on 61 patients with BMT[greater than or equal to]50 kg/[m.sup.2] operated by laparoscopic sleeve gastrectomy. Three gastric regions were analyzed by histopathology and immunohistology. Blood sample was taken before surgery, and at 6 and 12 months post-surgery, to study the plasma levels of ghrelin isoforms. Results: Ghrelin cells are present in all regions of the gastric mucosa, with a greater number in the body and the fundus. Difference was found in the antrum between male and female patients (p=0.018). Patients with arterial hypertension also showed a lower level of cells in antrum (p Conclusion:Our patients show ghrelin cells in all areas of the stomach. Gender, comorbidities, and gastritis are determinant on gastric ghrelin-producing cells distribution. Keywords: ghrelin, cells, obesity, gastric, laparoscopic surgery
Introduction Obesity is a public health problem in the world. It affects quality of life, increases the risk of illness, and raises health-care costs in countries around the world. (1,2) [...]
Introduction Obesity is a public health problem in the world. It affects quality of life, increases the risk of illness, and raises health-care costs in countries around the world. (1,2) [...]