부산대학교 도서관

To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.jneuroim.2007.10.027 Byline: Benedicte Puissant-Lubrano (a)(b), Frederique Viala (c), Peter Winterton (d), Michel Abbal (a)(b), Michel Clanet (c), Antoine Blancher (a)(b) Keywords: Multiple sclerosis; Thymic function; Regulatory T cells; IFN-[beta] treatment; T cell subsets; CD45RC Abstract: We explored the parameters of central and peripheral tolerance in patients with stable relapsing-remitting multiple sclerosis, treated or not with IFN-[beta]. TREC-positive T cells were lower in patients compared with controls, mainly in CD4+ subset, compatible with a thymus dysfunction or an expansion of peripheral lymphocytes. Compared to controls, the frequency of activated CD4+CD25+ T cells was higher in patients without modification of the CD4+CD25.sup.high T cell proportion. The IFN-[beta]-treatment did not modify the TREC-positive cell frequency nor the naive/memory T cell subset percentage but was associated with lower blood lymphocyte count and a lower frequency of CD4+CD45RC.sup.high subset. Author Affiliation: (a) Laboratoire d'Immunogenetique Moleculaire, Universite Paul Sabatier, Faculte de medecine Toulouse-Rangueil, BAcentstiment A2, 133 Route de Narbonne, 31062 Toulouse cedex 4, France (b) Laboratoire d'Immunologie, CHU de Toulouse, HA[acute accent]pital Rangueil, 1 Avenue Jean Poulhes, TSA 50032, 31 059 Toulouse cedex 9, France (c) Departement de Neurologie, CHU de Toulouse, HA[acute accent]pital Purpan, Place du Docteur Baylac, TSA 40031, 31 059 Toulouse cedex 9, France (d) Universite Paul Sabatier, 118 Route de Narbonne 31062 Toulouse cedex 4, France Article History: Received 11 July 2007; Revised 8 October 2007; Accepted 24 October 2007 Article Note: (footnote) [star] Sponsorship: This study was supported by the Ministere de la Recherche (Contract EA 3034) and ARSEP (Association pour la Recherche contre la Sclerose en Plaques) and Toulouse Teaching Hospital, France for regulatory and ethic submission.