학술논문

Increased susceptibility to ultraviolet-B and carcinogens of mice lacking the DNA excision repair gene XPA

Document Type

Academic Journal

Author

Vries, Annemieke de; Oostorm, Conny Th. M. van; Hofhuis, Frans M.A.; Dortant, Paul M.; Berg, Rob J.W.; Gruiji, Frank R. de; Wester, Piet W.; Kreiji, Coen F. van; Capel, Peter J.A.; Steeg, Harry van; Verbeek, Sjef J.

Source

Nature. Sept 14, 1995, Vol. 377 Issue 6545, p169, 5 p.

Subject

Ultraviolet radiation -- Physiological aspects
Xeroderma pigmentosum -- Physiological aspects
DNA -- Physiological aspects
Carcinogens -- Physiological aspects
Environmental issues
Science and technology
Zoology and wildlife conservation

Language

ISSN

0028-0836

Abstract

Group-A Xeroderma pigmentosum (XPA)-deficient mice show high vulnerability to ultraviolet-B-induced and 7,12-dimethylbenz-(a) anthracene (DMBA)-induced skin and eye carcinogenesis. These results reveal that XPA-deficient mice are excellent mimics of the human Xeroderma pigmentosum phenotype. The potential of XPA-deficient mice for studying the high rates of skin cancers due to ultraviolet radiation and chemical carcinogens is discussed.

Online Access

Full Text (Nature Journals) Full Text (ProQuest Central) Web of Science JCR 저널정보 Scopus Find it@PNU

이메일

부산대학교 도서관

Online Access

메일 발송