학술논문
Benign Pancreatic Hyperenzymemia, Also Known as Gullo's Syndrome
Case Study
Case Study
Document Type
Disease/Disorder overview
Author
Source
Laboratory Medicine. July 2020, Vol. 51 Issue 4, p423, 3 p.
Subject
Language
English
ISSN
0007-5027
Abstract
Benign pancreatic hyperenzymemia (BPH) is a syndrome first described by Lucio Gullo in 1996 (1) in 18 asymptomatic adults. It is characterized by an elevation of pancreatic enzymes (amylase, isoamylase, [...]
Benign pancreatic hyperenzymemia, also known as Gullo's syndrome, is a little-known syndrome first described in 1996 in patients studied for an elevation of pancreatic enzymes while otherwise being asymptomatic. We describe the case of a 2-year-old patient who was found to have significant elevation of amylase and lipase levels while he was asymptomatic. Blood tests and imaging tests were performed to determine the etiology, but they gave normal results. The enzyme elevation can even be 10 times the normal value of the enzyme, and only 1 enzyme may elevate, although most often all pancreatic enzymes are elevated. The etiology is not known, although several hypotheses have been suggested. This enzyme elevation is described both in adults and children and also sporadically or with a familial pattern. Knowledge of it can limit the performance of the multiple complementary test, some of which are very invasive in patients who have elevated pancreatic enzymes while they are asymptomatic. It knowledge allows us to confirm a benign prognosis about it and reassure the family about this disease and that in the end it will not require aggressive treatments such as surgery or chemotherapy. Keywords: bening pancreatitis, hyperenzymemia, Gullo's syndrome, pancreatic enzymes, pancreatic disease
Benign pancreatic hyperenzymemia, also known as Gullo's syndrome, is a little-known syndrome first described in 1996 in patients studied for an elevation of pancreatic enzymes while otherwise being asymptomatic. We describe the case of a 2-year-old patient who was found to have significant elevation of amylase and lipase levels while he was asymptomatic. Blood tests and imaging tests were performed to determine the etiology, but they gave normal results. The enzyme elevation can even be 10 times the normal value of the enzyme, and only 1 enzyme may elevate, although most often all pancreatic enzymes are elevated. The etiology is not known, although several hypotheses have been suggested. This enzyme elevation is described both in adults and children and also sporadically or with a familial pattern. Knowledge of it can limit the performance of the multiple complementary test, some of which are very invasive in patients who have elevated pancreatic enzymes while they are asymptomatic. It knowledge allows us to confirm a benign prognosis about it and reassure the family about this disease and that in the end it will not require aggressive treatments such as surgery or chemotherapy. Keywords: bening pancreatitis, hyperenzymemia, Gullo's syndrome, pancreatic enzymes, pancreatic disease