학술논문

Pharmacological validation of a novel nonhuman primate measure of thermal responsivity with utility for predicting analgesic effects
Document Type
Clinical report
Source
Journal of Pain Research. Annual, 2018, Vol. 11, p735, 7 p.
Subject
Primates
Pain management
Morphine
Medical research
Chronic pain
Diazepam
Analgesia
Clinical trials
Language
English
ISSN
1178-7090
Abstract
Introduction: The development of novel analgesics to treat acute or chronic pain has been a challenge due to a lack of translatable measurements. Preclinical end points with improved translatability are necessary to more accurately inform clinical testing paradigms, which may help guide selection of viable drug candidates. Methods: In this study, a nonhuman primate biomarker which is sensitive to standard analgesics at clinically relevant plasma concentrations, can differentiate analgesia from sedation and utilizes a protocol very similar to that which can be employed in human clinical studies is described. Specifically, acute heat stimuli were delivered to the volar forearm using a contact heat thermode in the same manner as the clinical setting. Results: Clinically efficacious exposures of morphine, fentanyl, and tramadol produced robust analgesic effects, whereas doses of diazepam that produce sedation had no effect. Conclusion: We propose that this assay has predictive utility that can help improve the probability of success for developing novel analgesics. Keywords: pain, opioid, translatable, monkey, thermode, noxious heat
Introduction There is an unmet need for pain relief medicines with improved efficacy and reduced side effects relative to the current standards of care. Recent efforts aimed at developing novel [...]