학술논문
A TEL-JAK2 fusion protein with constitutive kinase activity in human leukemia
Document Type
Academic Journal
Author
Source
Science. November 14, 1997, Vol. 278 Issue 5341, p1309, 4 p.
Subject
Language
English
ISSN
0036-8075
Abstract
The Janus family of tyrosine kineses (JAK) plays an essential role in development and in coupling cytokine receptors to downstream intracellular signaling events. A t(9,12)(p24;p13) chromosomal translocation in a T cell childhood acute lymphoblastic leukemia patient was characterized and shown to fuse the 3' portion of JAK2 to the 5' region of TEL, a gene encoding a member of the ETS transcription factor family. The TEL-JAK2 fusion protein includes the catalytic domain of JAK2 and the TEL-specific oligomerization domain. TEL-induced oligomerization of TEL-JAK2 resulted in the constitutive activation of its tyrosine kinase activity and conferred cytokine-independent proliferation to the interleukin-3--dependent Ba/F3 hematopoletic cell line.
Chromosomal translocations in human tumors frequently produce fusion genes whose chimeric protein products play an essential role in oncogenesis (1). TEL is located on chromosome 12p13 and is frequently involved […]
Chromosomal translocations in human tumors frequently produce fusion genes whose chimeric protein products play an essential role in oncogenesis (1). TEL is located on chromosome 12p13 and is frequently involved […]