부산대학교 도서관

Introduction We wished to characterize the relationship of advanced age to clinical outcomes and to transcriptomic responses after severe blunt traumatic injury with hemorrhagic shock. Methods We performed epidemiological, cytokine, and transcriptomic analyses on a prospective, multi-center cohort of 1,928 severely injured patients. Results We found that there was no difference in injury severity between the aged (age [greater than or equai to]55, n = 533) and young (age Conclusions We concluded that advanced age is one of the strongest non-injury related risk factors for poor outcomes after severe trauma with hemorrhagic shock and is associated with an altered and unique peripheral leukocyte genomic response. As the general population's age increases, it will be important to individualize prediction models and therapeutic targets to this high risk cohort.
Author(s): Erin L Vanzant[sup.1] , Rachael E Hilton[sup.1] , Cecilia M Lopez[sup.2] , Jianyi Zhang[sup.1] , Ricardo F Ungaro[sup.1] , Lori F Gentile[sup.1] , Benjamin E Szpila[sup.1] , Ronald V [...]