학술논문
Necrotizing enterocolitis in a newborn following intravenous immunoglobulin treatment for haemolytic disease
Document Type
Report
Author
Source
Journal of the College of Physicians and Surgeons Pakistan. August 1, 2013, Vol. 23 Issue 8, p598, 3 p.
Subject
Language
English
ISSN
1022-386X
Abstract
INTRODUCTION Blood group incompatibilities are most frequent and severe conditions causing hyperbilirubinaemia in the neonatal period. (1) Phototherapy and in severe cases exchange transfusion are used to prevent kernicterus and [...]
ABO iso-immunization is the most frequent haemolytic disease of the newborn. Treatment depends on the total serum bilirubin level, which may increase very rapidly in the first 48 hours of life in cases of haemolytic disease of the newborn. Phototherapy and, in severe cases, exchange transfusion are used to prevent hyperbilirubinaemic encephalopathy. Intravenous immunoglobulins (IVIG) are used to reduce exchange transfusion. Herein, we present a female newborn who was admitted to the NICU because of ABO immune haemolytic disease. After two courses of 1 g/kg of IVIG infusion, she developed necrotizing enterocolitis (NEC). Administration of IVIG to newborns with significant hyperbilirubinaemia due to ABO haemolytic disease should be cautiously administered and followed for complications. Key Words: Necrotizing enterocolitis. Hyperbilirubinaemia. Newborn. Intravenous immunoglobulins. Iso-immunization.
ABO iso-immunization is the most frequent haemolytic disease of the newborn. Treatment depends on the total serum bilirubin level, which may increase very rapidly in the first 48 hours of life in cases of haemolytic disease of the newborn. Phototherapy and, in severe cases, exchange transfusion are used to prevent hyperbilirubinaemic encephalopathy. Intravenous immunoglobulins (IVIG) are used to reduce exchange transfusion. Herein, we present a female newborn who was admitted to the NICU because of ABO immune haemolytic disease. After two courses of 1 g/kg of IVIG infusion, she developed necrotizing enterocolitis (NEC). Administration of IVIG to newborns with significant hyperbilirubinaemia due to ABO haemolytic disease should be cautiously administered and followed for complications. Key Words: Necrotizing enterocolitis. Hyperbilirubinaemia. Newborn. Intravenous immunoglobulins. Iso-immunization.