학술논문
Interferon-alpha acts at the preoptic hypothalamus to reduce natural killer cytotoxicity in rats
Document Type
Academic Journal
Source
The American Journal of Physiology. June, 1995, Vol. 268 Issue 6, pR1406, 5 p.
Subject
Language
ISSN
0002-9513
Abstract
The splenic natural killer (NK) activity cells in rats and mice are about 60 percent suppressed by the recombinant human interferon-alpha (rhIFN-alpha) through the medial preoptic hypothalamus-sympathetic pathway. Injection of rhIFN-alpha into other parts of the hypothalamus has no effect. The splenic denervation completely prevented the immunosuppression caused by the medial preoptic hypothalamus-rhIFN-alpha. The adrenalectomy has no effect on it.