학술논문
Sterol biosynthesis regulates TLR signaling and the innate immune response in a Smith-Lemli-Opitz syndrome model
Document Type
Letter to the editor
Author
Source
Journal of Clinical Investigation. March 15, 2024, Vol. 134 Issue 6
Subject
Language
English
ISSN
0021-9738
Abstract
To the Editor: TLRs are activated in cholesterol-enriched lipid raft membrane microdomains (1). Depleting raft cholesterol attenuates proinflammatory signaling by TLR4, the receptor for bacterial LPS. However, raft cholesterol has [...]