부산대학교 도서관

To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.amjhyper.2005.01.006 Byline: Kazuko Masuo (a)(b), Tomohiro Katsuya (b), Yuxiao Fu (b), Hiromi Rakugi (b), Toshio Ogihara (b), Michael L. Tuck (c) Keywords: Insulin resistance; sympathetic nerve activity; [beta].sub.2- and [beta].sub.3-adrenoceptor polymorphisms; blood pressure; obesity Abstract: The genes responsible for insulin resistance are also candidate genes for insulin resistance-related diseases, such as obesity and hypertension. Functional polymorphisms in the [beta].sub.2- and [beta].sub.3-adrenergic receptors have been reported to be associated with diabetes, hypertension, and obesity. To clarify the relevance of the [beta]-adrenergic receptor polymorphisms to insulin resistance, we studied their association with polymorphisms of [beta].sub.2 (Arg16Gly, Gln27Glu) and [beta].sub.3 (Trp64Arg) adrenoceptor genes. Author Affiliation: (a) Human Neurotransmitter Laboratory, Baker Heart Research Institute, Melbourne, Victoria, Australia (b) Department of Geriatric Medicine, Osaka University Graduate School of Medicine, Suita, Osaka, Japan (c) Endocrinology and Metabolism Division, Sepulveda Veterans Affairs Medical Center and David Geffen, University of California-Los Angeles School of Medicine, Los Angeles, California. Article History: Received 21 November 2004; Revised 29 December 2004; Accepted 12 January 2005