학술논문
Plasmids pIP419 and pIP421 from Bacteroides: 5-nitroimidazole resistance genes and their upstream insertion sequence elements
Document Type
Academic Journal
Source
Microbiology. April 1995, Vol. 141 Issue 4, p927, 9 p. chart
Subject
Language
ISSN
1350-0872
Abstract
A study of the genetic composition of two different 5-nitroimidazole (5-Ni) resistance genes, nimC and nimD, from Bacteroides plasmids pIP419 and pIP421 reveals that the nimC and the nimD regulate the synthesis of polypeptides. The genetic composition is important because Bacteroides are still susceptible to 5-Ni antibiotics, yet resist treatment from beta-lactam antibiotics. The gene sequences nimC and nimD were found to have resistant determinate structures, the nucleotide sequences and an identical insertion element, similar to those of nimA and nimB. The insertion sequence triggers the formation of those resistance genes.