학술논문
Efficacy of Secukinumab in Psoriasis: Post Hoc Gender-Wise Analysis of the SUPREME Study
Document Type
Academic Journal
Author
Stingeni, Luca; Malara, Giovanna; Conti, Andrea; Di Costanzo, Luisa; Carrera, Carlo Giovanni; Burlando, Martina; Malagoli, Piergiorgio; Musumeci, Maria Letizia; Bardazzi, Federico; Brazzelli, Valeria; Amerio, Paolo; De Simone, Clara; Trevisini, Sara; Balato, Anna; Megna, Matteo; Loconsole, Francesco; De Felice, Catia; Bartezaghi, Marta; Rausa, Alice; Aloisi, Elisabetta; Orsenigo, Roberto; Costanzo, Antonio
Source
Clinical, Cosmetic and Investigational Dermatology. January 31, 2023, Vol. 15, p27, 12 p.
Subject
Language
English
ISSN
1178-7015
Abstract
Purpose: Psoriasis, a common systemic inflammatory disorder, presents with gender-related differences in the quality of life (QoL) and treatment outcomes. This post hoc analysis from the Phase 3b SUPREME study explored gender-related differences in patient characteristics and efficacy of secukinumab 300 mg on Psoriasis Area and Severity Index (PASI) 75/90/100 and impact on QoL using the Dermatology Life Quality Index (DLQI) in patients with moderate to severe psoriasis through week 24. Patients and Methods: The proportion of patients achieving PASI 75/90/100 was computed using a nonresponder imputation approach. Differences between cohorts were analyzed using a logistic regression model. The mean change from baseline in DLQI was computed using the Wilcoxon test. Results: Among the 433 patients (males: 71.6%), females had a higher DLQI than males at baseline (13.1 vs 9.5; P Conclusion: In summary, secukinumab was effective in the treatment of psoriasis, irrespective of gender. Keywords: plaque psoriasis, PASI, patient-reported outcomes, Dermatology Quality of Life Index, Hospital Anxiety and Depression Scale
Introduction Psoriasis is a common systemic inflammatory disorder affecting the skin with a significant impact on patients' quality of life (QoL). (1,2) It occurs in both men and women; however, [...]
Introduction Psoriasis is a common systemic inflammatory disorder affecting the skin with a significant impact on patients' quality of life (QoL). (1,2) It occurs in both men and women; however, [...]