학술논문
THE RELATIONSHIP BETWEEN sTREM-1 AND ACTIVATION OF INFLAMMATORY BOWEL DISEASES/INFLAMATUAR BARSAK HASTALIKLARI AKTIVASYONU ILE sTREM-1 ARASINDAKI ILISKI
RESEARCH/ARASTIRMA
triggering receptor expressed on myeloid cells-1
RESEARCH/ARASTIRMA
triggering receptor expressed on myeloid cells-1
Document Type
Report
Author
Source
Journal of Istanbul Faculty of Medicine. September 2021, Vol. 84 Issue 3, p318, 6 p.
Subject
Language
English
ISSN
1305-6433
Abstract
INTRODUCTION In general, inflammatory bowel disease (IBD) refers to two major diseases: Ulcerative colitis (UC) and Crohn's disease (CD). Though UC and CD have different pathologic and clinical characteristics, the [...]
Objective: In inflammatory bowel disease (IBD), there is no reliable biomarker, yet. We aimed to determine whether Serum Soluble Triggering Receptor Expressed on Myeloid Cells-1 (sTREM-1) could be useful as a marker for the diagnosis and/or the determination of disease activity in patients with IBD. Material and Method: A total of 47 patients with ulcerative colitis (UC) and 25 patients with Crohn's disease (CD) were prospectively enrolled. Clinical disease activity was analyzed using the Crohn's Disease Activity Index (CDAI) for CD and the Truelove-Witts index for UC. Results: sTREM-1 levels were significantly lower in patients with IBD compared to healthy controls (p=0.001). In comparison of the levels of sTREM-1 between the different groups (CD, UC, and healthy controls) the difference was statistically significant. No considerable differences in sTREM-1 levels were determined in patients with active versus quiescent disease. The sTREM-1 levels negatively correlated with C-reactive protein, blood neutrophil-lymphocyte ratio, and positively with haemoglobin levels. Conclusion: sTREM-1 levels are decreased in IBD patients compared with the healthy individuals. It may, therefore, be useful for the diagnosis of IBD. However, it does not seem to be a precise marker of disease activity in IBD and cannot be suggested for assessing disease activity in these patients. Keywords: sTREM-1, inflammatory bowel diseases, Crohn's disease, ulcerative colitis Amac: Inflamatuar barsak hastaliklari (IBS) tanisinda henuz uygun bir biyobelirtec bulunmamistir. Calismamizda STREM-1 molekulunun bir belirtec olarak, IBS tanisinda ve hastalik aktivitesini belirlemede uygunlugunu belirlemeyi amacladik. Gerec ve Yontem: Toplam 47 ulseratif kolit ve 25 Crohn hastaligi tanili vaka calismaya dahil edildi. Crohn hastaligi icin aktiviteyi belirlemede Crohn Hastaligi Aktivite Indeksi (CDAI), ulseratif kolit icin ise Truelove-Witts indeksi kullanildi. Bulgular: Saglikli grupla kiyaslandiginda, sTREM-1 molekulu, IBS hastalarinda anlamli derecede dusuk saptandi. Ulseratif kolit, Crohn hastaligi ve saglikli grup arasinda sTREM-1 molekulu kiyaslandiginda ise fark istatiksel olarak anlamliydi. Aktif ve remisyonda olan hastalarda sTREM-1 duzeylerinde onemli bir fark bulunmamistir. sTREM-1 seviyeleri C-reaktif protein, notrofil-lenfosit orani ve hemoglobin duzeyleri ile negatif korelasyon gosterdi. Sonuc: sTREM-1 seviyeleri IBS'de saglikli bireylere gore daha dusuktur. IBS tanisi icin yararli olabilir. Ancak, IBS'de hastalik aktivitesinin belirlemede dogru bir belirtec gibi gorunmemektedir ve bu hastalarda hastaligin aktivitesini degerlendirmek icin onerilemez. Anahtar Kelimeler: sTREM-1, inflamatuar barsak hastaliklari, Crohn hastaligi, ulseratif kolit
Objective: In inflammatory bowel disease (IBD), there is no reliable biomarker, yet. We aimed to determine whether Serum Soluble Triggering Receptor Expressed on Myeloid Cells-1 (sTREM-1) could be useful as a marker for the diagnosis and/or the determination of disease activity in patients with IBD. Material and Method: A total of 47 patients with ulcerative colitis (UC) and 25 patients with Crohn's disease (CD) were prospectively enrolled. Clinical disease activity was analyzed using the Crohn's Disease Activity Index (CDAI) for CD and the Truelove-Witts index for UC. Results: sTREM-1 levels were significantly lower in patients with IBD compared to healthy controls (p=0.001). In comparison of the levels of sTREM-1 between the different groups (CD, UC, and healthy controls) the difference was statistically significant. No considerable differences in sTREM-1 levels were determined in patients with active versus quiescent disease. The sTREM-1 levels negatively correlated with C-reactive protein, blood neutrophil-lymphocyte ratio, and positively with haemoglobin levels. Conclusion: sTREM-1 levels are decreased in IBD patients compared with the healthy individuals. It may, therefore, be useful for the diagnosis of IBD. However, it does not seem to be a precise marker of disease activity in IBD and cannot be suggested for assessing disease activity in these patients. Keywords: sTREM-1, inflammatory bowel diseases, Crohn's disease, ulcerative colitis Amac: Inflamatuar barsak hastaliklari (IBS) tanisinda henuz uygun bir biyobelirtec bulunmamistir. Calismamizda STREM-1 molekulunun bir belirtec olarak, IBS tanisinda ve hastalik aktivitesini belirlemede uygunlugunu belirlemeyi amacladik. Gerec ve Yontem: Toplam 47 ulseratif kolit ve 25 Crohn hastaligi tanili vaka calismaya dahil edildi. Crohn hastaligi icin aktiviteyi belirlemede Crohn Hastaligi Aktivite Indeksi (CDAI), ulseratif kolit icin ise Truelove-Witts indeksi kullanildi. Bulgular: Saglikli grupla kiyaslandiginda, sTREM-1 molekulu, IBS hastalarinda anlamli derecede dusuk saptandi. Ulseratif kolit, Crohn hastaligi ve saglikli grup arasinda sTREM-1 molekulu kiyaslandiginda ise fark istatiksel olarak anlamliydi. Aktif ve remisyonda olan hastalarda sTREM-1 duzeylerinde onemli bir fark bulunmamistir. sTREM-1 seviyeleri C-reaktif protein, notrofil-lenfosit orani ve hemoglobin duzeyleri ile negatif korelasyon gosterdi. Sonuc: sTREM-1 seviyeleri IBS'de saglikli bireylere gore daha dusuktur. IBS tanisi icin yararli olabilir. Ancak, IBS'de hastalik aktivitesinin belirlemede dogru bir belirtec gibi gorunmemektedir ve bu hastalarda hastaligin aktivitesini degerlendirmek icin onerilemez. Anahtar Kelimeler: sTREM-1, inflamatuar barsak hastaliklari, Crohn hastaligi, ulseratif kolit