학술논문
Down-regulating effect of nicotine on connexin43 gap junctions in human umbilical vein endothelial cells is attenuated by statins
Document Type
Academic Journal
Source
European Journal of Cell Biology. Jan, 2004, Vol. 82 Issue 12, p589, 7 p.
Subject
Language
English
ISSN
0171-9335
Abstract
To link to full-text access for this article, visit this link: http://dx.doi.org/10.1078/0171-9335-00348 Byline: Cheng-Ho Tsai (a), Hung-I Yeh (a), Tin-Yi Tian (a), Yi-Nan Lee (a), Chi-Sheng Lu (a), Yu-Shien Ko (b) Keywords: Nicotine; connexin43; endothelial cells; nAChRs; statin Abstract: We investigated the effect of nicotine on connexin43 (Cx43) expression and gap-junctional communication in human umbilical vein endothelial cells (HUVEC). We also evaluated whether the effect requires activation of acetyl choline receptors sensitive to nicotine (nAChRs) and is altered by statins. The results showed that expression of Cx43 protein is reduced by nicotine in a dose-dependent manner (6x10.sup.-4 M nicotine vs control, 33% reduction, p Author Affiliation: (a) Departments of Internal Medicine and Medical Research, Mackay Memorial Hospital, Mackay Junior College of Nursing, Taipei Medical University, Taipei/Taiwan (b) The First Cardiovascular Division, Department of Internal Medicine, Chang Gung Memorial Hospital, Taipei/Taiwan Article History: Received 5 June 2003; Revised 7 October 2003; Accepted 14 October 2003