학술논문
Lung parenchymal calcifications in a child with cystic fibrosis
Document Type
Report
Source
Respirology Case Reports. May 2022, Vol. 10 Issue 5
Subject
Language
English
Abstract
INTRODUCTION Cystic fibrosis (CF) is a multi‐system disease that results in chronic pulmonary suppuration and bronchiectasis.[sup.1] Pulmonary calcifications are typically caused through two mechanisms, the dystrophic and metastatic forms. Although [...]
: We describe a 6‐year‐old girl with homozygous p.Phe508del cystic fibrosis with severe multi‐lobar bronchiectasis and obstructive lung disease who was found to have prominent parenchymal calcifications in the right middle lobe on a computed tomography scan of the chest. Histopathology from the calcified area of lung biopsy showed fibrous tissue with chronic inflammation with CD3+ T‐lymphocytes and macrophages with no granulomas. Dystrophic calcification was seen within this necrotic debris.
: We describe a 6‐year‐old girl with homozygous p.Phe508del cystic fibrosis with severe multi‐lobar bronchiectasis and obstructive lung disease who was found to have prominent parenchymal calcifications in the right middle lobe on a computed tomography scan of the chest. Histopathology from the calcified area of lung biopsy showed fibrous tissue with chronic inflammation with CD3+ T‐lymphocytes and macrophages with no granulomas. Dystrophic calcification was seen within this necrotic debris.