학술논문
Identification and expression cloning of a leptin receptor, OB-R
Document Type
Academic Journal
Author
Tartaglia, Louis A.; Dembski, Marlene; Weng, Xun; Deng, Nanhua; Culpepper, Janice; Devos, Rene; Richards, Grayson J.; Campfield, L. Arthur; Clark, Frederick T.; Deeds, Jim; Muir, Craig; Sanker, Sean; Moriarty, Ann; Moore, Karen J.; Smutko, John S.; Mays, Gail G.; Woolf, Elizabeth A.; Monroe, Cheryl A.; Tepper, Robert I.
Source
Cell. Dec 29, 1995, Vol. 83 Issue 7, p1263, 9 p.
Subject
Language
ISSN
0092-8674
Abstract
A cDNA isolated from the mouse choroid plexus encodes a high affinity leptin receptor (OB-R) that bears structural homology to the class I cytokine receptors. The amino acid sequence of OB-R is most similar to the receptors of leukemia inhibitory factor, granulocyte colony-stimulating factor and interleukin-6. The gene encoding the OB-R is present in the diabetes gene locus. OB-R is a single membrane spanning receptor. The OB-R mRNA may also be expressed in tissues such as the hypothalamus. The protein leptin is produced by the obesity gene and controls the body weight homeostasis.