학술논문
Novel loci for childhood body mass index and shared heritability with adult cardiometabolic traits
Document Type
Report
Author
Vogelezang, Suzanne; Bradfield, Jonathan P.; Ahluwalia, Tarunveer S.; Curtin, John A.; Lakka, Timo A.; Grarup, Niels; Scholz, Markus; van der Most, Peter J.; Monnereau, Claire; Stergiakouli, Evie; Heiskala, Anni; Horikoshi, Momoko; Fedko, Iryna O.; Vilor-Tejedor, Natalia; Cousminer, Diana L.; Standl, Marie; Wang, Carol A.; Viikari, Jorma; Geller, Frank; Íñiguez, Carmen; Pitkänen, Niina; Chesi, Alessandra; Bacelis, Jonas; Yengo, Loic; Torrent, Maties; Ntalla, Ioanna; Helgeland, Øyvind; Selzam, Saskia; Vonk, Judith M.; Zafarmand, Mohammed H.; Heude, Barbara; Farooqi, Ismaa Sadaf; Alyass, Akram; Beaumont, Robin N.; Have, Christian T.; Rzehak, Peter; Bilbao, Jose Ramon; Schnurr, Theresia M.; Barroso, Inês; Bønnelykke, Klaus; Beilin, Lawrence J.; Carstensen, Lisbeth; Charles, Marie-Aline; Chawes, Bo; Clément, Karine; Closa-Monasterolo, Ricardo; Custovic, Adnan; Eriksson, Johan G.; Escribano, Joaquin; Groen-Blokhuis, Maria; Grote, Veit; Gruszfeld, Dariusz; Hakonarson, Hakon; Hansen, Torben; Hattersley, Andrew T.; Hollensted, Mette; Hottenga, Jouke-Jan; Hyppönen, Elina; Johansson, Stefan; Joro, Raimo; Kähönen, Mika; Karhunen, Ville; Kiess, Wieland; Knight, Bridget A.; Koletzko, Berthold; Kühnapfel, Andreas; Landgraf, Kathrin; Langhendries, Jean-Paul; Lehtimäki, Terho; Leinonen, Jaakko T.; Li, Aihuali; Lindi, Virpi; Lowry, Estelle; Bustamante, Mariona; Medina-Gomez, Carolina; Melbye, Mads; Michaelsen, Kim F.; Morgen, Camilla S.; Mori, Trevor A.; Nielsen, Tenna R. H.; Niinikoski, Harri; Oldehinkel, Albertine J.; Pahkala, Katja; Panoutsopoulou, Kalliope; Pedersen, Oluf; Pennell, Craig E.; Power, Christine; Reijneveld, Sijmen A.; Rivadeneira, Fernando; Simpson, Angela; Sly, Peter D.; Stokholm, Jakob; Teo, Kook K.; Thiering, Elisabeth; Timpson, Nicholas J.; Uitterlinden, André G.; van Beijsterveldt, Catharina E. M.; van Schaik, Barbera D. C.; Vaudel, Marc; Verduci, Elvira; Vinding, Rebecca K.; Vogel, Mandy; Zeggini, Eleftheria; Sebert, Sylvain; Lind, Mads V.; Brown, Christopher D.; Santa-Marina, Loreto; Reischl, Eva; Frithioff-Bøjsøe, Christine; Meyre, David; Wheeler, Eleanor; Ong, Ken; Nohr, Ellen A.; Vrijkotte, Tanja G. M.; Koppelman, Gerard H.; Plomin, Robert; Njølstad, Pål R.; Dedoussis, George D.; Froguel, Philippe; Sørensen, Thorkild I. A.; Jacobsson, Bo; Freathy, Rachel M.; Zemel, Babette S.; Raitakari, Olli; Vrijheid, Martine; Feenstra, Bjarke; Lyytikäinen, Leo-Pekka; Snieder, Harold; Kirsten, Holger; Holt, Patrick G.; Heinrich, Joachim; Widén, Elisabeth; Sunyer, Jordi; Boomsma, Dorret I.; Järvelin, Marjo-Riitta; Körner, Antje; Davey Smith, George; Holm, Jens-Christian; Atalay, Mustafa; Murray, Clare; Bisgaard, Hans; McCarthy, Mark I.; Jaddoe, Vincent W. V.; Grant, Struan F. A.; Felix, Janine F.
Source
PLoS Genetics. October 12, 2020, Vol. 16 Issue 10, pe1008718
Subject
Language
English
ISSN
1553-7390
Abstract
The genetic background of childhood body mass index (BMI), and the extent to which the well-known associations of childhood BMI with adult diseases are explained by shared genetic factors, are largely unknown. We performed a genome-wide association study meta-analysis of BMI in 61,111 children aged between 2 and 10 years. Twenty-five independent loci reached genome-wide significance in the combined discovery and replication analyses. Two of these, located near NEDD4L and SLC45A3, have not previously been reported in relation to either childhood or adult BMI. Positive genetic correlations of childhood BMI with birth weight and adult BMI, waist-to-hip ratio, diastolic blood pressure and type 2 diabetes were detected (R.sub.g ranging from 0.11 to 0.76, P-values
Author(s): Suzanne Vogelezang 1,2,3, Jonathan P. Bradfield 4,5, Tarunveer S. Ahluwalia 6,7,8,9, John A. Curtin 10, Timo A. Lakka 11,12,13, Niels Grarup 8, Markus Scholz 14,15, Peter J. van der [...]
Author(s): Suzanne Vogelezang 1,2,3, Jonathan P. Bradfield 4,5, Tarunveer S. Ahluwalia 6,7,8,9, John A. Curtin 10, Timo A. Lakka 11,12,13, Niels Grarup 8, Markus Scholz 14,15, Peter J. van der [...]