부산대학교 도서관

Background: Metabolic acidosis is the most frequent medical condition occurring in critically ill renally compromised patients. This study was aimed to determine clinical outcomes of bicarbonate therapy in renally compromised critically ill patients having metabolic acidosis. Methods: A prospective longitudinal cohort study was undertaken in three military hospitals in Rawalpindi, Pakistan. All patients fulfilling the inclusion criteria who were admitted to the ICU of any of the three study hospitals from July 2019 to March 2020 were studied for clinical outcomes of bicarbonate therapy using an evidence-based clinical checklist. Outcome measures include changes in blood pH, serum potassium, and sodium levels, blood pressure and weight, along with other clinically significant laboratory parameters. Results: Eighty-one patients fulfilling the inclusion criteria were evaluated. The mean age of the patients was 55.61[+ or -]19.5 years, while the mean weight was 63.43[+ or -]14.19 Kg. A mortality rate of 45.7% was observed. Disease-related complications including hypoxia, cardiac failure, multiple organ failure, elevated blood pressure, and ischemic heart disease (IHD) were found to be associated with a higher mortality rate (P Conclusion: Bicarbonate therapy was not found to affect the mortality rate in critically ill renally compromised patients with metabolic acidosis. Keywords: metabolic acidosis, chronic kidney disease, bicarbonate therapy, clinical outcomes, mortality rate
Introduction Metabolic acidosis has become a significant ailment that is represented as inequity within the body's acid-base equilibrium. It frequently occurs in critically ill patients with an overall prevalence of [...]