학술논문
Dynamic GABAergic afferent modulation of AgRP neurons
gamma aminobutyric acid; and agouti-related peptide
gamma aminobutyric acid; and agouti-related peptide
Document Type
Report
Author
Source
Nature Neuroscience. December 2016, Vol. 19 Issue 12, p1628, 8 p.
Subject
Language
English
ISSN
1097-6256
Abstract
Author(s): Alastair S Garfield (corresponding author) [1, 2]; Bhavik P Shah [1]; Christian R Burgess [1]; Monica M Li [1]; Chia Li [3, 4]; Jennifer S Steger [1]; Joseph C [...]
Agouti-related peptide (AgRP) neurons of the arcuate nucleus of the hypothalamus (ARC) promote homeostatic feeding at times of caloric insufficiency, yet they are rapidly suppressed by food-related sensory cues before ingestion. Here we identify a highly selective inhibitory afferent to AgRP neurons that serves as a neural determinant of this rapid modulation. Specifically, GABAergic projections arising from the ventral compartment of the dorsomedial nucleus of the hypothalamus (vDMH) contribute to the preconsummatory modulation of ARC[sup.AgRP] neurons. In a manner reciprocal to ARC[sup.AgRP] neurons, ARC-projecting leptin receptor-expressing GABAergic vDMH neurons exhibit rapid activation upon availability of food that additionally reflects the relative value of the food. Thus, leptin receptor-expressing GABAergic vDMH neurons form part of the sensory network that relays real-time information about the nature and availability of food to dynamically modulate ARC[sup.AgRP] neuron activity and feeding behavior.
Agouti-related peptide (AgRP) neurons of the arcuate nucleus of the hypothalamus (ARC) promote homeostatic feeding at times of caloric insufficiency, yet they are rapidly suppressed by food-related sensory cues before ingestion. Here we identify a highly selective inhibitory afferent to AgRP neurons that serves as a neural determinant of this rapid modulation. Specifically, GABAergic projections arising from the ventral compartment of the dorsomedial nucleus of the hypothalamus (vDMH) contribute to the preconsummatory modulation of ARC[sup.AgRP] neurons. In a manner reciprocal to ARC[sup.AgRP] neurons, ARC-projecting leptin receptor-expressing GABAergic vDMH neurons exhibit rapid activation upon availability of food that additionally reflects the relative value of the food. Thus, leptin receptor-expressing GABAergic vDMH neurons form part of the sensory network that relays real-time information about the nature and availability of food to dynamically modulate ARC[sup.AgRP] neuron activity and feeding behavior.