학술논문
COVID-19 through Adverse Outcome Pathways: Building Networks to Better Understand the Disease--3rd CIAO AOP Design Workshop
Document Type
Academic Journal
Author
Clerbaux, Laure-Alix; Amigo, Nuria; Amorim, Maria Joao; Bal-Price, Anna; Leite, Sofia Batista; Beronius, Anna; Bezemer, Gillina F.G.; Bostroem, Ann-Charlotte; Carusi, Annamaria; Coecke, Sandra; Concha, Rachel; Daskalopoulos, Evangelos P.; Debernardi, Francesca; Edrosa, Eizleayne; Edwards, Steve W.; Filipovska, Julija; Garcia-Reyero, Natalia; Gavins, Felicity N.E.; Halappanavar, Sabina; Hargreaves, Alan J.; Hogberg, Helena T.; Huynh, Mylene T.; Jacobson, Daniel; Josephs-Spaulding, Jonathan; Kim, Young Jun; Kong, Hyun Joon; Krebs, Catharine E.; Lam, Ann; Landesmann, Brigitte; Layton, Adrienne Racanelli; Lee, Yong Oh; Macmillan, Donna S.; Mantovani, Alberto; Margiotta-Casaluci, Luigi; Martens, Marvin; Masereeuw, Rosalinde; Mayasich, Sally A.; Mei, Liang Merlin; Mortensen, Holly; Munoz, Amalia; Nymark, Penny; Ohayon, Elan; Ojasi, Joshi Manoj; Paini, Alicia; Parissis, Nikolaos; Parvatam, Surat; Pistollato, Francesca; Sachana, Magdalini; Sorli, Jorid Birkelund; Sullivan, Kristie M.; Sund, Jukka; Tanabe, Shihori; Tsaioun, Katya; Vinken, Mathieu; Viviani, Laura; Waspe, Jennifer; Willett, Catherine; Wittwehr, Clemens
Source
ALTEX: Alternatives to Animal Experimentation. Spring 2022, Vol. 39 Issue 2, p322, 14 p.
Subject
Language
English
ISSN
1868-596X
Abstract
On April 28-29, 2021, 50 scientists from different fields of expertise met for the 3rd online CIAO workshop. The CIAO project 'Modelling the Pathogenesis of COVID-19 using the Adverse Outcome Pathway (AOP) framework' aims at building a holistic assembly of the available scientific knowledge on COVID-19 using the AOP framework. An individual AOP depicts the disease progression from the initial contact with the SARS-CoV-2 virus through biological key events (KE) toward an adverse outcome such as respiratory distress, anosmia or multiorgan failure. Assembling the individual AOPs into a network highlights shared KEs as central biological nodes involved in multiple outcomes observed in COVID-19 patients. During the workshop, the KEs and AOPs established so far by the CIAO members were presented and positioned on a timeline of the disease course. Modulating factors influencing the progression and severity of the disease were also addressed as well as factors beyond purely biological phenomena. CIAO relies on an interdisciplinary crowdsourcing effort, therefore, approaches to expand the CIAO network by widening the crowd and reaching stakeholders were also discussed. To conclude the workshop, it was decided that the AOPs/KEs will be further consolidated, integrating virus variants and long COVID when relevant, while an outreach campaign will be launched to broaden the CIAO scientific crowd.
1 Introduction 1.1 The CIAO project Coronavirus disease 2019 (COVID-19) is an ongoing global health emergency. Researchers around the world have mobilized to investigate the biological mechanisms of the disease, [...]
1 Introduction 1.1 The CIAO project Coronavirus disease 2019 (COVID-19) is an ongoing global health emergency. Researchers around the world have mobilized to investigate the biological mechanisms of the disease, [...]