학술논문
Presence and diagnostic value of circulating tsncRNA for ovarian tumor
Document Type
Report
Author
Source
Molecular Cancer. November 22, 2018, Vol. 17 Issue 1
Subject
Language
English
ISSN
1476-4598
Abstract
Author(s): Eric Y. Peng[sup.1,2] , Yang Shu[sup.1,3] , Yuke Wu[sup.4] , Feier Zeng[sup.1] , Shuangyan Tan[sup.1] , Yun Deng[sup.1] , Yiqi Deng[sup.1] , Haining Chen[sup.5] , Lei Zhu[sup.1] and Heng [...]
tRNA-derived small non-coding RNAs (tsncRNAs), a class of newly defined small non-coding RNA, have been considered to be involved in various cellular biological processes through regulating gene expression at both transcriptional and post-transcriptional level. However, the presence of circulating tsncRNAs and their diagnostic potential is largely unclear. In this study, we investigate the serum-derived public transcriptome data from ovarian tumor patients and non-cancer controls, and find that circulating tsncRNAs cover a high proportion of total small RNA and are non-random degradation products in serum (ranging from 2.5-29.4%), which are enriched in several specific types of related tRNA (e.g., Gly-tRNA). Particularly, four tsncRNAs are differentially expressed in serum from cancer patients compared to those from healthy controls, and can predict abnormal cell proliferation with high accuracy. Our results reveal the ubiquitous presence of circulating tsncRNAs in serum, and diagnostic potential of specific tsncRNAs for ovarian tumor. Keywords: Non-coding RNA, Circulating tsncRNA, tRNA
tRNA-derived small non-coding RNAs (tsncRNAs), a class of newly defined small non-coding RNA, have been considered to be involved in various cellular biological processes through regulating gene expression at both transcriptional and post-transcriptional level. However, the presence of circulating tsncRNAs and their diagnostic potential is largely unclear. In this study, we investigate the serum-derived public transcriptome data from ovarian tumor patients and non-cancer controls, and find that circulating tsncRNAs cover a high proportion of total small RNA and are non-random degradation products in serum (ranging from 2.5-29.4%), which are enriched in several specific types of related tRNA (e.g., Gly-tRNA). Particularly, four tsncRNAs are differentially expressed in serum from cancer patients compared to those from healthy controls, and can predict abnormal cell proliferation with high accuracy. Our results reveal the ubiquitous presence of circulating tsncRNAs in serum, and diagnostic potential of specific tsncRNAs for ovarian tumor. Keywords: Non-coding RNA, Circulating tsncRNA, tRNA