학술논문
Mexiletine infusion challenge test for neonatal long QT syndrome with 2:1 atrioventricular block
Document Type
Report
Author
Source
Journal of Arrhythmia. August 2019, Vol. 35 Issue 4, p685, 4 p.
Subject
Language
English
ISSN
1880-4276
Abstract
INTRODUCTION Long QT syndrome (LQTS) causes sudden cardiac death due to ventricular arrhythmias such as Torsades de Pointes (TdP) or ventricular fibrillation (VF). Functional 2:1 atrioventricular block (AVB), one of [...]
: For applying a genotype‐based treatment in neonatal long QT syndrome (LQTS), early detection of the genotype becomes an important issue. We report a case of a neonate with LQTS type 3 that presented with 2:1 atrioventricular block and underwent a mexiletine infusion challenge test, and achieved shortening of the QTc and 1:1 atrioventricular conduction. The mexiletine infusion challenge test was helpful to make an early detection of the genotype of the LQTS and predicted the drug efficacy in a neonatal patient.
: For applying a genotype‐based treatment in neonatal long QT syndrome (LQTS), early detection of the genotype becomes an important issue. We report a case of a neonate with LQTS type 3 that presented with 2:1 atrioventricular block and underwent a mexiletine infusion challenge test, and achieved shortening of the QTc and 1:1 atrioventricular conduction. The mexiletine infusion challenge test was helpful to make an early detection of the genotype of the LQTS and predicted the drug efficacy in a neonatal patient.