부산대학교 도서관

Purpose: MR planimetry of brainstem structures can be helpful for the discrimination of parkinsonian syndromes. It has been suggested that ageing might influence brainstem MR measurements assessed by MR planimetry. Gender-effects on planimetric measurements have never been investigated so far. The aim of this study was to evaluate age--and gender effects on brainstem MR-planimetric measures. Methods: Brainstem MR-planimetric measures including brainstem diameters (midbrain, pons, middle and superior cerebellar peduncle) and areas (pontine and midbrain), the ratios derived from both mid-brain-to-pons diameters and areas as well as the Magnetic Resonance Parkinson Index (MRPI) were assessed on 1.5 Tesla weighted MR images in a large cohort of 97 healthy controls. Results: Effects of gender were observed on both pontine measurements (diameter and area). Effects of age were shown on midbrain measurements (area and diameter), as well as on combined planimetric measurements (MRPI and ratios derived from both midbrain-to-pons diameters and areas). There were neither gender nor age effects on combined measurements nor midbrain diameter in the population aged 50 to 80 years, the age-range relevant for the differential diagnosis of neurodegenerative parkinsonism. Conclusion: Although age and gender might influence single brainstem planimetric MR measures, our results indicate that there is no need for age- or gender-specific cut-offs for the relevant age group.
https://doi.org/10.1007/S00062-018-0719-8 Stephanie Mangesius *, (1), Anna Hussl (2), Susanne Tagwercher (2), Eva Reiter (2), Christoph Muller (2), Florian Krismer (2), Philipp Mahlknecht (2), Michael Schocke (3), Elke R. Gizewski (3), [...]