학술논문
Global mortality from dementia: Application of a new method and results from the Global Burden of Disease Study 2019
Document Type
Report
Author
Nichols, Emma; Abd‐Allah, Foad; Abdoli, Amir; Abosetugn, Akine Eshete; Abrha, Woldu Aberhe; Abualhasan, Ahmed; Abu‐Gharbieh, Eman; Akinyemi, Rufus Olusola; Alahdab, Fares; Alanezi, Fahad Mashhour; Alipour, Vahid; Ansari, Iman; Arabloo, Jalal; Ashraf‐Ganjouei, Amir; Avan, Abolfazl; Ayano, Getinet; Babar, Zaheer‐Ud‐Din; Baig, Atif Amin; Banach, Maciej; Barboza, Miguel A.; Barker‐Collo, Suzanne Lyn; Baune, Bernhard T.; Bhagavathula, Akshaya Srikanth; Bhattacharyya, Krittika; Bijani, Ali; Biondi, Antonio; Birhan, Tsegaye Adane; Biswas, Atanu; Bolla, Srinivasa Rao; Boloor, Archith; Brayne, Carol; Brenner, Hermann; Burkart, Katrin; Burns, Richard A.; Nagaraja, Sharath Burugina; Carvalho, Felix; Castro‐De‐Araujo, Luis F.S.; Catalá‐López, Ferrán; Cerin, Ester; Cernigliaro, Achille; Cherbuin, Nicolas; Choi, Jee‐Young Jasmine; Chu, Dinh‐Toi; Dagnew, Baye; Dai, Xiaochen; Dandona, Lalit; Dandona, Rakhi; Diaz, Daniel; Forooshani, Zahra Sadat Dibaji; Douiri, Abdel; Duncan, Bruce B.; Edvardsson, David; El‐Jaafary, Shaimaa I.; Eskandari, Khalil; Eskandarieh, Sharareh; Feigin, Valery L.; Fereshtehnejad, Seyed‐Mohammad; Fernandes, Eduarda; Ferrara, Pietro; Filip, Irina; Fischer, Florian; Gaidhane, Shilpa; Gebregzabiher, Kidane Zereabruk; Ghashghaee, Ahmad; Gholamian, Asadollah; Gnedovskaya, Elena V.; Golechha, Mahaveer; Gupta, Rajeev; Hachinski, Vladimir; Hamidi, Samer; Hankey, Graeme J.; Haro, Josep Maria; Hassan, Amr; Hay, Simon I.; Heidari, Golnaz; Heidari‐Soureshjani, Reza; Househ, Mowafa; Hussain, Rabia; Hwang, Bing‐Fang; Ilic, Irena M.; Ilic, Milena D.; Irvani, Seyed Sina Naghibi; Iso, Hiroyasu; Iwagami, Masao; Jha, Ravi Prakash; Kalani, Rizwan; Kandel, Himal; Karch, André; Kasa, Ayele Semachew; Kengne, Andre Pascal; Kim, Young‐Eun; Kim, Yun Jin; Kisa, Sezer; Kisa, Adnan; Kivimäki, Mika; Komaki, Hamidreza; Koyanagi, Ai; Kukull, Walter A.; Kumar, G. Anil; Kumar, Manasi; Landires, Iván; Leonardi, Matilde; Lim, Stephen S.; Liu, Xuefeng; Logroscino, Giancarlo; Lopez, Alan D.; Lorkowski, Stefan; Loy, Clement T.; Amin, Hawraz Ibrahim M.; Manafi, Navid; Manjunatha, Narayana; Mehndiratta, Man Mohan; Menezes, Ritesh G.; Meretoja, Atte; Merkin, Alexander; Metekiya, Workua Mekonnen; Misganaw, Awoke Temesgen; Mohajer, Bahram; Ibrahim, Norlinah Mohamed; Mohammad, Yousef; Mohapatra, Archisman; Mohebi, Farnam; Mokdad, Ali H.; Mondello, Stefania; Mossie, Tilahun Belete; Mulugeta, Anwar; Nagel, Gabriele; Naveed, Muhammad; Nayak, Vinod C.; Kandel, Sandhya Neupane; Nguyen, Son Hoang; Nguyen, Huong Lan Thi; Nuñez‐Samudio, Virginia; Ogbo, Felix Akpojene; Olagunju, Andrew T.; Orru, Hans; Ostojic, Sergej M.; Ostroff, Samuel M.; Otstavnov, Nikita; Otstavnov, Stanislav S.; Owolabi, Mayowa O.; Pathak, Mona; Toroudi, Hamidreza Pazoki; Peterson, Carrie B.; Pham, Hai Quang; Phillips, Michael R.; Piradov, Michael A.; Pottoo, Faheem Hyder; Prada, Sergio I.; Pribadi, Dimas Ria Angga; Radfar, Amir; Raggi, Alberto; Rahim, Fakher; Ram, Pradhum; Rana, Juwel; Rashedi, Vahid; Rawaf, Salman; Rawaf, David Laith; Reinig, Nickolas; Rezaei, Nima; Robinson, Stephen R.; Romoli, Michele; Sachdev, Perminder S.; Sahathevan, Ramesh; Sahebkar, Amirhossein; Sahraian, Mohammad Ali; Sattin, Davide; Saylan, Mete; Sayyah, Mehdi; Schiavolin, Silvia; Schmidt, Maria Inês; Shahid, Izza; Shaikh, Masood Ali; Shigematsu, Mika; Shin, Jae Il; Shiri, Rahman; Siddiqi, Tariq Jamal; Silva, João Pedro; Singh, Jasvinder A.; Soheili, Amin; Spurlock, Emma Elizabeth; Szoeke, Cassandra E I.; Tabarés‐Seisdedos, Rafael; Taddele, Biruk Wogayehu; Thakur, Bhaskar; Thekkepurakkal, Akhil Soman; Tovani‐Palone, Marcos Roberto; Tran, Bach Xuan; Travillian, Ravensara S.; Tripathi, Manjari; Tsegaye, Gebiyaw Wudie; Usman, Muhammad Shariq; Vacante, Marco; Velazquez, Diana Zuleika; Venketasubramanian, Narayanaswamy; Vidale, Simone; Vlassov, Vasily; Wang, Yuan‐Pang; Wei, Jingkai; Weiss, Jordan; Weldemariam, Abrha Hailay; Wimo, Anders; Wu, Chenkai; Yadollahpour, Ali; Yamagishi, Kazumasa; Yeshitila, Yordanos Gizachew; Yonemoto, Naohiro; Zadey, Siddhesh; Zhang, Zhi‐Jiang; Murray, Christopher J.L.; Vos, Theo
Source
Alzheimer’s & Dementia: Translational Research & Clinical Interventions. July 2021, Vol. 7 Issue 1
Subject
Language
English
Abstract
INTRODUCTION While there is a wealth of evidence indicating that individuals with dementia have a higher risk for mortality, the mechanisms by which dementia leads to death are less clear.[sup.1] [...]
: Introduction: Dementia is currently one of the leading causes of mortality globally, and mortality due to dementia will likely increase in the future along with corresponding increases in population growth and population aging. However, large inconsistencies in coding practices in vital registration systems over time and between countries complicate the estimation of global dementia mortality. Methods: We meta‐analyzed the excess risk of death in those with dementia and multiplied these estimates by the proportion of dementia deaths occurring in those with severe, end‐stage disease to calculate the total number of deaths that could be attributed to dementia. Results: We estimated that there were 1.62 million (95% uncertainty interval [UI]: 0.41–4.21) deaths globally due to dementia in 2019. More dementia deaths occurred in women (1.06 million [0.27–2.71]) than men (0.56 million [0.14–1.51]), largely but not entirely due to the higher life expectancy in women (age‐standardized female‐to‐male ratio 1.19 [1.10–1.26]). Due to population aging, there was a large increase in all‐age mortality rates from dementia between 1990 and 2019 (100.1% [89.1–117.5]). In 2019, deaths due to dementia ranked seventh globally in all ages and fourth among individuals 70 and older compared to deaths from other diseases estimated in the Global Burden of Disease (GBD) study. Discussion: Mortality due to dementia represents a substantial global burden, and is expected to continue to grow into the future as an older, aging population expands globally.
: Introduction: Dementia is currently one of the leading causes of mortality globally, and mortality due to dementia will likely increase in the future along with corresponding increases in population growth and population aging. However, large inconsistencies in coding practices in vital registration systems over time and between countries complicate the estimation of global dementia mortality. Methods: We meta‐analyzed the excess risk of death in those with dementia and multiplied these estimates by the proportion of dementia deaths occurring in those with severe, end‐stage disease to calculate the total number of deaths that could be attributed to dementia. Results: We estimated that there were 1.62 million (95% uncertainty interval [UI]: 0.41–4.21) deaths globally due to dementia in 2019. More dementia deaths occurred in women (1.06 million [0.27–2.71]) than men (0.56 million [0.14–1.51]), largely but not entirely due to the higher life expectancy in women (age‐standardized female‐to‐male ratio 1.19 [1.10–1.26]). Due to population aging, there was a large increase in all‐age mortality rates from dementia between 1990 and 2019 (100.1% [89.1–117.5]). In 2019, deaths due to dementia ranked seventh globally in all ages and fourth among individuals 70 and older compared to deaths from other diseases estimated in the Global Burden of Disease (GBD) study. Discussion: Mortality due to dementia represents a substantial global burden, and is expected to continue to grow into the future as an older, aging population expands globally.