부산대학교 도서관

In the gastrointestinal tract, tachykinin N[K.sub.1] receptors are widely distributed in a number of neuronal and nonneuronal cells involved in the control of gut motor activity. In particular, in the rabbit isolated distal colon, which is a suitable model system to investigate the contribution of tachykinins as noncholinergic excitatory transmitters, the influence of N[K.sub.1] receptors in the regulation of peristalsis is not known. The selective N[K.sub.1]-receptor antagonists SR-140333 (0.3 and 1 nM) and MEN-10930 (0.3-10 nM) significantly enhanced the velocity of rabbit colonic propulsion to submaximal stimulation. The prokinetic effect of SR-140333 was prevented by [N.sup.[omega]]-nitro-L-arginine (L-NNA), a nitric oxide synthase inhibitor, indicating that N[K.sub.1] receptors located on nitrergic innervation exert a functional inhibitory restraint on the circular muscle and probably on descending excitatory and inhibitory pathways during propulsion. Conversely, the selective N[K.sub.1]-receptor agonist septide (3-10 nM) significantly inhibited colonic propulsion. In the presence of L-NNA, the inhibitory effect of septide was reverted into a prokinetic effect, which is probably mediated by the activation of postjunctional excitatory N[K.sub.1] receptors. myenteric neurons; excitatory pathways; inhibitory pathways