학술논문
Role of cytostolic Ca2+ and protein kinase C in developing myogenic contraction in isolated rat small arteries
Document Type
Academic Journal
Author
Source
The American Journal of Physiology. March, 1997, Vol. 272 Issue 3, pH1165, 8 p.
Subject
Language
ISSN
0002-9513
Abstract
The interaction between protein kinase C activity and intracellular Ca2+ ([Ca2+]i) during myogenic contraction was analyzed in isolated rat skeletal muscles and mesenteric small arteries with fura 2. Myogenic contraction in isolated rat skeletal muscles and small arteries was attenuated by the inhibition of PKC with staurosporine without altering [Ca2+]i elevations in the skeletal muscles and small arteries. Furthermore, the effects of staurosporine indicated the cooperative role of PKC and [Ca2+]i elevations in the promotion of myogenic contraction.