학술논문
Knee Osteoarthritis Therapy: Recent Advances in Intra-Articular Drug Delivery Systems
Document Type
Academic Journal
Author
Source
Drug Design, Development and Therapy. May 31, 2022, Vol. 16, p1311, 37 p.
Subject
Language
English
ISSN
1177-8881
Abstract
Drug delivery for osteoarthritis (OA) treatment is a continuous challenge because of their poor bioavailability and rapid clearance in joints. Intra-articular (IA) drug delivery is a common strategy and its therapeutic effects depend mainly on the efficacy of the drug-delivery system used for OA therapy. Different types of IA drug-delivery systems, such as microspheres, nanoparticles, and hydrogels, have been rapidly developed over the past decade to improve their therapeutic effects. With the continuous advancement in OA mechanism research, new drugs targeting specific cell/signaling pathways in OA are rapidly evolving and effective drug delivery is critical for treating OA. In this review, recent advances in various IA drug-delivery systems for OA treatment, OA targeted strategies, and related signaling pathways in OA treatment are summarized and analyzed based on current publications. Keywords: osteoarthritis, knee, drug delivery, intra-articular
Introduction Osteoarthritis (OA) is the most common degenerative joint disease that affects approximately more than 300 million people worldwide. (1,) Knee OA(KOA) accounts for approximately 85% of all OA cases [...]
Introduction Osteoarthritis (OA) is the most common degenerative joint disease that affects approximately more than 300 million people worldwide. (1,) Knee OA(KOA) accounts for approximately 85% of all OA cases [...]