학술논문
COLLECTING DUCT CARCINOMA AND ENDEMIC NEPHROPATHY - CASE REPORTS AND LITERATURE REVIEW/KARCINOM SABIRNIH KANALICA I ENDEMSKA NEFROPATIJA - PRIKAZI SLUCAJA I PREGLED LITERATURE
Case Report
Case Report
Document Type
Clinical report
Author
Source
Acta Clinica Croatica. September 2020, Vol. 59 Issue 3, p539, 4 p.
Subject
Language
English
ISSN
0353-9466
Abstract
Introduction Collecting duct carcinoma (CDC) or Bellini duct carcinoma is a rare epithelial neoplasm of the kidney that accounts for 0.4% to 2.6% of all renal neoplasms1. These tumors behave [...]
Although collecting duct carcinoma is a subtype of renal cell carcinoma, several studies implicate association with urothelial carcinoma. The coexistence of collecting duct carcinoma and another renal neoplasm is rare. Endemic nephropathy is a renal disease causing chronic renal failure. It is highly associated with urothelial neoplasm and occurs in endemic villages in Bosnia, Croatia, Bulgaria, Romania and Serbia. Recent studies have confirmed the important role of exposure to aristolochic acid as an etiologic factor. We present three cases of collecting duct carcinoma with literature overview. In one case, we describe collecting duct carcinoma with metachronous urothelial carcinoma of the pyelon and urinary bladder in an endemic nephropathy patient. To our knowledge, this is the first case report describing this coexistence. Certain similarities between collecting duct carcinoma and urothelial carcinoma were found, e.g., higher incidence in female compared to male, higher mean age, and multifocal and multicentric occurrence of the tumor. Our observations support the hypothesis that collecting duct carcinoma and urothelial carcinoma could be connected. Key words: Collecting duct carcinoma; Bellini duct carcinoma; Endemic nephropathy; Kidney neoplasm; Renal failure; Urothelial carcinoma Iako je karcinom sabirnih kanalica podvrsta karcinoma bubreznih stanica, odredena istrazivanja ukazuju na povezanost ovog entiteta s karcinomom prijelaznog epitela. Istodobna pojava karcinoma sabirnih kanalica i drugih bubreznih neoplazma je rijetka. Endemska nefropatija je bubrezna bolest koja dovodi do kronicnog bubreznog zatajenja. Vrlo je povezana s urotelnim tumorima i javlja se u endemskim selima u Bosni, Hrvatskoj, Bugarskoj, Rumunjskoj i Srbiji. Nedavna istrazivanja potvrdila su znacajnu ulogu izlozenosti aristolohicnoj kiselini kao etioloskom cimbeniku. Predstavljamo tri slucaja karcinoma sabirnih kanalica s pregledom literature. U jednom slucaju opisujemo karcinom sabirnih kanalica s metakronom pojavom urotelnog karcinoma pijelona te mokracnog mjehura u bolesnika s potvrdenom endemskom nefropatijom. Prema nasim saznanjima ovo je prvi slucaj koji opisuje ovakvu koegzistenciju. Pronadene su odredene slicnosti izmedu karcinoma sabirnih kanalica i karcinoma prijelaznog epitela, a to su veca ucestalost u zenskoj populaciji, visa prosjecna dob, multifokalna i multicentricna pojava tumora. Nasa zapazanja podupiru hipotezu o mogucoj povezanosti karcinoma sabirnih kanalica i karcinoma prijelaznog epitela. Kljucne rijeci: Karcinom sabirnih kanalica; Karcinom Bellinijeva kanalica; Endemska nefropatija; Bubrezna novotvorina; Bubrezno zatajenje; Karcinom urotela
Although collecting duct carcinoma is a subtype of renal cell carcinoma, several studies implicate association with urothelial carcinoma. The coexistence of collecting duct carcinoma and another renal neoplasm is rare. Endemic nephropathy is a renal disease causing chronic renal failure. It is highly associated with urothelial neoplasm and occurs in endemic villages in Bosnia, Croatia, Bulgaria, Romania and Serbia. Recent studies have confirmed the important role of exposure to aristolochic acid as an etiologic factor. We present three cases of collecting duct carcinoma with literature overview. In one case, we describe collecting duct carcinoma with metachronous urothelial carcinoma of the pyelon and urinary bladder in an endemic nephropathy patient. To our knowledge, this is the first case report describing this coexistence. Certain similarities between collecting duct carcinoma and urothelial carcinoma were found, e.g., higher incidence in female compared to male, higher mean age, and multifocal and multicentric occurrence of the tumor. Our observations support the hypothesis that collecting duct carcinoma and urothelial carcinoma could be connected. Key words: Collecting duct carcinoma; Bellini duct carcinoma; Endemic nephropathy; Kidney neoplasm; Renal failure; Urothelial carcinoma Iako je karcinom sabirnih kanalica podvrsta karcinoma bubreznih stanica, odredena istrazivanja ukazuju na povezanost ovog entiteta s karcinomom prijelaznog epitela. Istodobna pojava karcinoma sabirnih kanalica i drugih bubreznih neoplazma je rijetka. Endemska nefropatija je bubrezna bolest koja dovodi do kronicnog bubreznog zatajenja. Vrlo je povezana s urotelnim tumorima i javlja se u endemskim selima u Bosni, Hrvatskoj, Bugarskoj, Rumunjskoj i Srbiji. Nedavna istrazivanja potvrdila su znacajnu ulogu izlozenosti aristolohicnoj kiselini kao etioloskom cimbeniku. Predstavljamo tri slucaja karcinoma sabirnih kanalica s pregledom literature. U jednom slucaju opisujemo karcinom sabirnih kanalica s metakronom pojavom urotelnog karcinoma pijelona te mokracnog mjehura u bolesnika s potvrdenom endemskom nefropatijom. Prema nasim saznanjima ovo je prvi slucaj koji opisuje ovakvu koegzistenciju. Pronadene su odredene slicnosti izmedu karcinoma sabirnih kanalica i karcinoma prijelaznog epitela, a to su veca ucestalost u zenskoj populaciji, visa prosjecna dob, multifokalna i multicentricna pojava tumora. Nasa zapazanja podupiru hipotezu o mogucoj povezanosti karcinoma sabirnih kanalica i karcinoma prijelaznog epitela. Kljucne rijeci: Karcinom sabirnih kanalica; Karcinom Bellinijeva kanalica; Endemska nefropatija; Bubrezna novotvorina; Bubrezno zatajenje; Karcinom urotela