부산대학교 도서관

To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.juro.2006.06.063 Byline: Julia S. Barthold (a), Xiaoli Si (a), Deborah Stabley (b), Katia Sol-Church (b), Liam Campion (a), Suzanne M. McCahan (c) Keywords: cryptorchidism; testis; LGR8 protein; rat; insulin-like growth factor binding protein 3; rats Abbreviations: GD, gestational day; Insl3, insulin-like 3; LE/orl, Long-Evans orl; LE/wt, Long-Evans wild-type; Lgr8, leucine rich repeat G protein coupled receptor 8; PCR, polymerase chain reaction; RT, reverse transcriptase; Tbp, TATA binding protein; Tpp2, tripeptidyl peptidase 2 Abstract: Failure of testicular descent occurs in about 65% of spontaneously cryptorchid Long-Evans orl rats. Development of the fetal gubernaculum is dependent on expression of leucine rich G protein coupled receptor (also known as G protein coupled receptor affecting testicular descent) and its ligand, insulin-like 3. We studied testicular descent and mRNA expression of insulin-like 3 and leucine rich G protein coupled receptor in Long-Evans orl and Long-Evans wild-type rats during perinatal development. Author Affiliation: (a) Urology Research Laboratory, A. I. duPont Hospital for Children/Nemours Children's Clinic, Wilmington, Delaware (b) Biomolecular Core Research Laboratory, A. I. duPont Hospital for Children/Nemours Children's Clinic, Wilmington, Delaware (c) Bioinformatics Research Laboratory, A. I. duPont Hospital for Children/Nemours Children's Clinic, Wilmington, Delaware Article History: Received 10 March 2006 Article Note: (footnote) Supported by Grant 1 P20 RR020173-01 from National Center for Research Resources, a component of National Institutes of Health. Contents are solely the responsibility of the authors and do not necessarily represent the official views of the National Center for Research Resources or the National Institutes of Health. Animal protocols received institutional animal care and use committee approval.