학술논문
Discovery of a novel, potent, and specific family of factor Xa inhibitors via combinatorial chemistry
Document Type
Academic Journal
Author
Source
Biochemistry. Jan 27, 1998, Vol. 37 Issue 4, p1053, 7 p. table
Subject
Language
ISSN
0006-2960
Abstract
Low molecular weight peptide inhibitors of factor Xa, important in the hemostatic mechanism, were identified by screening a combinatorial peptide library composed of L-amino acids. The peptides were modified into peptide mimetics with a greater than 1000-fold increase in potency while retaining unusual selectivity for factor Xa. Results suggested the potential uses of these peptides in anticoagulant therapy.