학술논문
Vitamin D Supplementation and Disease-Free Survival in Stage II Melanoma: A Randomized Placebo Controlled Trial
Document Type
Academic Journal
Author
Johansson, Harriet; Spadola, Giuseppe; Tosti, Giulio; Mandalà, Mario; Minisini, Alessandro M.; Queirolo, Paola; Aristarco, Valentina; Baldini, Federica; Cocorocchio, Emilia; Albertazzi, Elena; Zichichi, Leonardo; Cinieri, Saverio; Jemos, Costantino; Mazzarol, Giovanni; Gnagnarella, Patrizia; Macis, Debora; Tedeschi, Ines; Salè, Emanuela Omodeo; Stucci, Luigia Stefania; Bonanni, Bernardo; Testori, Alessandro; Pennacchioli, Elisabetta; Ferrucci, Pier Francesco; Gandini, Sara
Source
Nutrients. June, 2021, Vol. 13 Issue 6
Subject
Language
English
ISSN
2072-6643
Abstract
Patients with newly resected stage II melanoma (n = 104) were randomized to receive adjuvant vitamin D3 (100,000 IU every 50 days) or placebo for 3 years to investigate vitamin D3 protective effects on developing a recurrent disease. Median age at diagnosis was 50 years, and 43% of the patients were female. Median serum 25-hydroxy vitamin D (25OHD) level at baseline was 18 ng/mL, interquartile range (IQ) was 13–24 ng/mL, and 80% of the patients had insufficient vitamin D levels. We observed pronounced increases in 25OHD levels after 4 months in the active arm (median 32.9 ng/mL; IQ range 25.9–38.4) against placebo (median 19.05 ng/mL; IQ range 13.0–25.9), constantly rising during treatment. Remarkably, patients with low Breslow score (
Author(s): Harriet Johansson (corresponding author) [1,*]; Giuseppe Spadola [2]; Giulio Tosti [3]; Mario Mandalà [4,†]; Alessandro M. Minisini [5,†]; Paola Queirolo [6,†]; Valentina Aristarco [1]; Federica Baldini [3]; Emilia Cocorocchio [...]
Author(s): Harriet Johansson (corresponding author) [1,*]; Giuseppe Spadola [2]; Giulio Tosti [3]; Mario Mandalà [4,†]; Alessandro M. Minisini [5,†]; Paola Queirolo [6,†]; Valentina Aristarco [1]; Federica Baldini [3]; Emilia Cocorocchio [...]