학술논문
Effects of pertussis toxin on[alpha] .sub.1-agonist-mediated phosphatidylinositide turnover and myocardial cell hypertrophy in neonatal rat ventricular myocytes
Document Type
Academic Journal
Author
Source
Experientia. Jan, 1990, Vol. 46 Issue 1, p81, 4 p.
Subject
Language
English
ISSN
0014-4754
Abstract
In neonatal rat ventricular myocytes pretreatment with pertussis toxin did not affect 1 uM (-)-norepinephrine stimulation of inositol phosphates or myocardial cell hypertrophy as measured either by protein radiolabelling or by myocardial cell protein content. Thus guanine nucleotide protein (s) ADP-ribosylated by pertussis toxin do not play a role in two[alpha] .sub.1-adrenoceptor-mediated processes, phosphatidylinositide turnover and induction of myocardial cell hypertrophy.